675578-64-0

Basic information

• Product Name: Benzenesulfonamide, N-[5-chloro-2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethenyl]phenyl]-4- methyl-N-2-propenyl-
• CAS NO: 675578-64-0
• Molecular Formula: C24H32ClNO3SSi
• Molecular Weight: 478.127
• Mol File: 675578-64-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[5-chloro-2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethenyl]phenyl]-4- methyl-N-2-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[5-chloro-2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethenyl]phenyl]-4- methyl-N-2-propenyl-(675578-64-0)
• EPA Substance Registry System: Benzenesulfonamide, N-[5-chloro-2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethenyl]phenyl]-4- methyl-N-2-propenyl-(675578-64-0)

Safety Data

• Hazardous Substances Data: 675578-64-0(Hazardous Substances Data)

Upstream product

• 675578-62-8 N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide 
• 39061-72-8 2-acetyl-5-chloroaniline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 675578-63-9 N-allyl-N-p-toluenesulfonyl-2-acetyl-5-chloroaniline 

Downstream Products

• 86-98-6 4,7-dichloroquinoline 
• 86-99-7 7-chloro-4-hydroxylquinoline 
• 675578-65-1 N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline 

Relevant articles and documents

A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): Its application to the synthesis of key intermediates for anti-malarial agents

A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2- dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology.