675578-65-1

Basic information

• Product Name: N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline
• Synonyms: N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline
• CAS NO: 675578-65-1
• Molecular Weight: 450.074
• Mol File: 675578-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline(675578-65-1)
• EPA Substance Registry System: N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline(675578-65-1)

Safety Data

• Hazardous Substances Data: 675578-65-1(Hazardous Substances Data)

Upstream product

• 675578-62-8 N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 39061-72-8 2-acetyl-5-chloroaniline 
• 675578-64-0 N-allyl-N-p-toluenesulfonyl-2-[1-(tert-butyldimethylsilyloxy)vinyl]-5-chloroaniline 

Downstream Products

• 86-98-6 4,7-dichloroquinoline 
• 86-99-7 7-chloro-4-hydroxylquinoline 

Relevant articles and documents

A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): Its application to the synthesis of key intermediates for anti-malarial agents

A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2- dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology.