676500-67-7

Basic information

• Product Name: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide
• Synonyms: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide;2-PYRAZINECARBOXAMIDE, 5-[2-METHOXY-4-[[[2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHYL]AMINO]METHYL]PHENOXY]-
• CAS NO: 676500-67-7
• Molecular Formula: C₂₀H₂₆N₄O₄
• Molecular Weight: 386.44484
• Mol File: 676500-67-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 575.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.204±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: 14.06±0.50(Predicted)
• CAS DataBase Reference: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide(676500-67-7)
• EPA Substance Registry System: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide(676500-67-7)

Safety Data

• Hazardous Substances Data: 676500-67-7(Hazardous Substances Data)

Usage

Uses

Bevenopran, is a peripheral μ-opioid receptor antagonist.

Upstream product

• 65412-03-5 4-(2-aminoethyl)tetrahydropyran 

Relevant articles and documents

Synthesis method of bevenopran

The invention relates to a synthesis method of bevenopran. 3-methoxy-4-hydroxy hydroxy benzyl bromide and 5-chloropyrazine-2-formamide serve as raw materials, potassium carbonate serves as alkali, DMF serves as a solvent, heating coupling is carried out, and 5-(4-brooethyl-2-metoxy phenoxyl)pyrazine-2-formamide is synthesized; then the product and 2-(tetrahydropyrane-4-yl)ethyeneamine react in dichloromethane under the reflux condition with triethylamine serving as alkali to obtain the target product bevenopran. The invention provides the method for effectively synthesizing bevenopran. According to the method, fewer reaction steps exist, the yield is high, purification and other aftertreatment are simple, and industrial operation is easy to achieve.