67878-76-6Relevant articles and documents
N-substituted acrylamide derivatives as DHODH inhibitors and preparation and use of N-substituted acrylamide derivatives
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Paragraph 0245; 0250-0251, (2019/11/04)
The invention relates to N-substituted acrylamide derivatives as DHODH inhibitors and preparation and use of the N-substituted acrylamide derivatives. In particular, the invention discloses a compoundshown in a general formula I and the preparation and use of the compound. The compound has excellent DHODH inhibitory activation, so the compound can be used for treating or preventing various diseases caused by DHODH, the various diseases include but not limited to cancer, rheumatoid arthritis, lupus erythematosus, organ transplant rejection and other autoimmune diseases, and colitis, rhinitis and other inflammatory diseases.
Alternative and straightforward synthesis of dopaminergic 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
Oeztaskin, Necla,Goeksu, Sueleyman,Hasan Secen
experimental part, p. 2017 - 2024 (2011/06/24)
5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine was synthesized from 2-naphthoic acid in six steps with an overall yield of 27%. Following the reaction sequence, bromination, esterification, substitution with NaOMe in the presence of CuI, the Birch reducti
Design and Syntheses of 1,6-Naphthalene Derivatives as Selective HCMV Protease Inhibitors
Gopalsamy, Ariamala,Lim, Kitae,Ellingboe, John W.,Mitsner, Boris,Nikitenko, Antonia,Upeslacis, Janis,Mansour, Tarek S.,Olson, Matthew W.,Bebernitz, Geraldine A.,Grinberg, Diane,Feld, Boris,Moy, Franklin J.,O'Connell, John
, p. 1893 - 1899 (2007/10/03)
Through high throughput screening of various libraries, substituted styryl naphthalene 6 was identified as an HCMV protease inhibitor. Optimization of various regions of the lead molecule using parallel synthesis resulted in 1,6-substituted naphthalenes 1