53568-17-5

Basic information

• Product Name: 5-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
• Synonyms: 5-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
• CAS NO: 53568-17-5
• Molecular Weight: 0
• Mol File: 53568-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid(53568-17-5)
• EPA Substance Registry System: 5-Methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid(53568-17-5)

Safety Data

• Hazardous Substances Data: 53568-17-5(Hazardous Substances Data)

Upstream product

• 33567-59-8 (2-methoxy-phenyl)-acetaldehyde 
• 93-09-4 naphthalene-2-carboxylate 
• 117745-72-9 methyl 5-methoxy-1,2,3,4-tetrahydro-2-naphthoate 
• 5043-31-2 5-Methoxy-2-naphthoic acid 
• 1013-83-8 5-bromonaphthalene-2-carboxylic acid 
• 67878-76-6 5-bromo-2-naphthalenecarboxylic acid methyl ester 

Downstream Products

• 3880-88-4 SKF 87967 hydrochloride 
• 1309876-80-9 benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate 

Relevant articles and documents

Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C-H/C-H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F

The development of practical C-H/C-H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C-C bonds. Herein we report a cyclative C(sp3)-H/C(sp2)-H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected β-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na2CO3·1.5H2O2) as the sole oxidant and generates water as the only byproduct. A range of biologically important scaffolds, including tetralins, chromanes, and indanes, can be easily prepared by this protocol. Finally, the synthetic application of this methodology is demonstrated by the concise total synthesis of (±)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through sequential functionalizations of four C-H bonds.