681482-80-4 Usage
Description
1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine is a chemical compound that serves as an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication. 1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine plays a crucial role in the development of new treatments for tuberculosis, particularly against drug-resistant strains of Mycobacterium tuberculosis.
Uses
Used in Pharmaceutical Industry:
1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine is used as a key intermediate in the synthesis of Delamanid (D230660) for its role in inhibiting mycolic acid synthesis. This makes it a vital component in the production of a medication that demonstrates potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis, offering a potential solution for combating multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).
Check Digit Verification of cas no
The CAS Registry Mumber 681482-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,1,4,8 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 681482-80:
(8*6)+(7*8)+(6*1)+(5*4)+(4*8)+(3*2)+(2*8)+(1*0)=184
184 % 10 = 4
So 681482-80-4 is a valid CAS Registry Number.
681482-80-4Relevant articles and documents
Preparation method of aromatic amine intermediate
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Paragraph 0066; 0067; 0068; 0070; 0071; 0073; 0074, (2019/05/15)
The invention discloses a preparation method of an aromatic amine intermediate. The preparation method comprises the following steps: 1, in a polar aprotic solvent, under the presence of a catalyst, aligand and an alkali, a compound of formula III and a c
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles
Sasaki, Hirofumi,Haraguchi, Yoshikazu,Itotani, Motohiro,Kuroda, Hideaki,Hashizume, Hiroyuki,Tomishige, Tatsuo,Kawasaki, Masanori,Matsumoto, Makoto,Komatsu, Makoto,Tsubouchi, Hidetsugu
, p. 7854 - 7860 (2007/10/03)
In an effort to develop potent new antituberculosis agents that would be effective against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis, we prepared a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxaz
