287952-67-4

Basic information

• Product Name: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE
• Synonyms: Piperidine, 4-[4-(trifluoroMethoxy)phenoxy]-;4-[4-(TrifluoroMethoxy)phenoxy]piperidine HCl;Delamanid intermediate
• CAS NO: 287952-67-4
• Molecular Formula: C₁₂H₁₄F₃NO₂
• Molecular Weight: 261.25
• Mol File: 287952-67-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 71-73℃
• Boiling Point: 292.2°Cat760mmHg
• Flash Point: 130.5°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0.00151mmHg at 25°C
• Refractive Index: 1.473
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.65±0.10(Predicted)
• CAS DataBase Reference: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE(287952-67-4)
• EPA Substance Registry System: 4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE(287952-67-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 287952-67-4(Hazardous Substances Data)

Usage

Uses

4-[4-(Trifluoromethoxy)phenoxy]piperidine is used in the preparation of 3,5-disubstituted isoxazolines as antituberculosis agents.

InChI:InChI=1/C12H14F3NO/c13-12(14,15)9-1-3-10(4-2-9)17-11-5-7-16-8-6-11/h1-4,11,16H,5-8H2

Upstream product

• 1083099-51-7 1-ethoxycarbonyl-4-(4-trifluoromethoxy-phenoxy)-piperidine 
• 1083099-54-0 4-(4-trifluoromethoxy-phenoxy)-pyridine 
• 828-27-3 4-Trifluoromethoxyphenol 
• 65214-82-6 4-hydroxy-piperidine-1-carboxylic acid ethyl ester 
• 287952-21-0 4-[(4-trifluoromethoxy)phenyl]methoxypiperidine-1-formic acid tert-butyl ester 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 
• 287952-66-3 tert-butyl 4-(4-(trifluoromethoxy)phenoxy)piperidin-1-carboxylate 
• 1501963-64-9 4-(4-(trifluoromethoxy)phenoxy)piperidine hydrochloride 

Downstream Products

• 681482-80-4 1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine 
• 1083099-55-1 1-(4-benzyloxy-phenyl)-4-(4-trifluoromethoxy-phenoxy)-piperidine 
• 1145961-59-6 C₂₀H₂₀F₃NO₂ 
• 866109-93-5 4-(4-(4-trifluoromethoxy-phenoxy)piperidin-1-yl)phenol para-toluenesulfonic acid salt 
• 1318735-00-0 (R)-2-methyl-3-(4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)propane-1,2-diol 
• 1318735-08-8 4-[4-(trifluoromethoxy)phenoxy]-1-{4-[(2,2,4-trimethyl-1,3-dioxolan-4-yl)methoxy]phenyl}piperidine 
• 1318734-91-6 2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol 
• 1318734-93-8 (S)-4-[4-(trifluoromethoxy)phenoxy]-1-{4-[(2,2,4-trimethyl-1,3-dioxolan-4-yl)methoxy]phenyl}piperidine 
• 1346017-83-1 ethyl 3-(4-((4-trifluoromethoxy)phenoxy)piperidin-1-yl)propionate 
• 1346017-85-3 3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)propionic acid 
• 1346017-93-3 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionyl chloride 
• 1346017-94-4 ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate 
• 1346017-95-5 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid 
• 1346017-61-5 (S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide 

Relevant articles and documents

METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF

The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the step of heating hydroquinone and 4-(4-trifluoromethoxyphenoxy)piperidine. This method can produce 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof in an industrially advantageous manner.

Method for preparing highly pure Delamanid intermediate

The invention provides a method for preparing a highly pure delamanid intermediate. The intermediate is 4-[4-(trifluoromethoxy)phenoxyl]piperidine. Hydrogen chloride is dissolved in ethyl acetate in a Boc group removal step, and the dissolvability difference between the above product and impurities in ethylene acetate is used to carry out purification, so a column chromatography purifying method using tedious operation is avoided, the final product with high yield and high purity is also obtained, the production cost is reduced, and the method is suitable for industrial large-scale production.

(6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

(6,7-Dihydro-2-nitro-5H-imidazo [2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the descripti