68164-77-2

Basic information

• Product Name: 2-Cyano-3,6-dimethylpyridine
• Synonyms: 2-Cyano-3,6-dimethylpyridine;3,6-dimethylpicolinonitrile;-Cyano-3,6-dimethylpyridine;3,6-diMethylpyridine-2-carbonitrile;3,6-diMethyl-2-Pyridinecarbonitrile
• CAS NO: 68164-77-2
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Mol File: 68164-77-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 99.6 °C
• Appearance: /
• Density: 1.05 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Cyano-3,6-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-3,6-dimethylpyridine(68164-77-2)
• EPA Substance Registry System: 2-Cyano-3,6-dimethylpyridine(68164-77-2)

Safety Data

• Hazardous Substances Data: 68164-77-2(Hazardous Substances Data)

Usage

General Description

2-Cyano-3,6-dimethylpyridine is a chemical compound with the molecular formula C7H7N. It is a derivative of pyridine and is commonly used as a building block in organic synthesis. 2-Cyano-3,6-dimethylpyridine is known for its ability to undergo various chemical reactions, including alkylation, acylation, and reduction, making it a versatile intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 2-Cyano-3,6-dimethylpyridine is also used as a ligand in coordination chemistry and as a catalyst in a variety of chemical reactions. It is important to handle this chemical with caution, as it is flammable and may cause skin and eye irritation upon contact.

Upstream product

• 4986-05-4 2,5-dimethylpyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 589-93-5 2,5-dimethylpyridine 
• 18368-76-8 2 chloro-3-methylpyridine 
• 557-21-1 zinc(II) cyanide 
• 72093-14-2 3-Methyl-2-chloro-6-methyl-pyridine 
• 151-50-8 potassium cyanide 
• 892665-90-6 2-cyano-3,6-dimethylpyridine 1-oxide 

Downstream Products

• 848774-90-3 (3,6-dimethylpyridin-2-yl)methanol 

Relevant articles and documents

EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds X1, X2, X3, X4, X5, X6, Q, L1, L2, Y, R1, R2, R3, R4, R5, R6, R7, R8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Preparation of cyanopyridines by direct cyanation

After pretreatment with nitric acid and trifluoroacetic anhydride, aqueous potassium cyanide converted pyridines 1a-1 into their corresponding 2-cyano derivatives 4a-1 in an average yield of 52%. Georg Thieme Verlag Stuttgart.