72093-14-2

Basic information

• Product Name: 2-Chloro-3,6-dimethylpyridine
• Synonyms: 2-Chloro-3,6-dimethylpyridine
• CAS NO: 72093-14-2
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.59812
• Mol File: 72093-14-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 200.8°C at 760 mmHg
• Flash Point: 93.7°C
• Appearance: /
• Density: 1.113g/cm³
• Vapor Pressure: 0.451mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.71±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3,6-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3,6-dimethylpyridine(72093-14-2)
• EPA Substance Registry System: 2-Chloro-3,6-dimethylpyridine(72093-14-2)

Safety Data

• Hazardous Substances Data: 72093-14-2(Hazardous Substances Data)

Usage

Description

2-Chloro-3,6-dimethylpyridine is an organic compound characterized by the presence of a chloro substituent at the 2nd position and methyl groups at the 3rd and 6th positions on a pyridine ring. It is a versatile intermediate in organic synthesis and possesses unique chemical properties that make it suitable for various applications.

Uses

Used in Pharmaceutical Industry:
2-Chloro-3,6-dimethylpyridine is used as a reactant in the preparation of resorcinol N-aryl amide compounds, which are pyruvate dehydrogenase kinase inhibitors. These inhibitors play a crucial role in the development of drugs targeting metabolic pathways associated with various diseases, including cancer and neurodegenerative disorders. 2-Chloro-3,6-dimethylpyridine's reactivity and structural features enable the synthesis of bioactive molecules with potential therapeutic applications.

InChI:InChI=1/C7H8ClN/c1-5-3-4-6(2)9-7(5)8/h3-4H,1-2H3

Upstream product

• 18368-76-8 2 chloro-3-methylpyridine 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 74-88-4 methyl iodide 
• 125014-90-6 Nitrile of 2-Methyl-2-chloro-5-oxohexanoic Acid 

Downstream Products

• 68164-77-2 3,6-dimethylpyridine-2-carbonitrile 

Relevant articles and documents

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Pyridylthio-acylanilide herbicides

Novel herbicidally active pyridylthio-acylanilides of the formula STR1 in which R1, R2 and R3, independently of one another, represent hydrogen, halogen, cyano or trifluoromethyl or alkyl, alkoxy and alkylthio having 1 to 4 carbon atoms in each case, R4 represents halogen, methyl or methoxy, n represents a number 0, 1 or 2, z represents the group (Ia) STR2 or the group (Ib) STR3 where X represents oxygen, sulphur, an N--R10 or N--O--R11 group, or X and Rg tpgether represent the STR4 radical, and the other radicals can have various meanings. Intermediates of the formulae STR5 are also new.