68206-45-1 Usage
Description
3-Nitro-2-pyridinesulfenyl chloride (NpysCl) is an organic compound that serves as a crucial intermediate in the synthesis of various chemical compounds, particularly in the field of pharmaceuticals and biochemistry. It is characterized by its reactive nature and the presence of a nitro group and a pyridinesulfenyl chloride group, which contribute to its versatility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
3-NITRO-2-PYRIDINESULFENYL CHLORIDE is used as a starting material for the synthesis of N-, O-, and S-Npys-protected amino acids. This application is essential in the development of new drugs and therapeutic agents, as it allows for the protection and activation of specific functional groups in amino acids, facilitating their incorporation into complex molecular structures.
Used in Biochemistry Research:
3-NITRO-2-PYRIDINESULFENYL CHLORIDE is used as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides. This application is crucial in the study of protein structure and function, as it enables the formation of disulfide bonds, which are essential for the stability and activity of many proteins.
Used in Chemical Synthesis:
3-NITRO-2-PYRIDINESULFENYL CHLORIDE is used as a reagent in the preparation of various organic compounds, taking advantage of its reactive nature and the presence of functional groups that can participate in a wide range of chemical reactions. This application is valuable in the development of new materials and compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Purification Methods
The chloride crystallises as yellow needles from CH2Cl2. When pure, it is stable for several weeks at room temperature, and no decomposition was observed after 6 months at <0o. It is moisture sensitive. UV (MeCN) has at 231nm max ( 12,988), 264nm ( 5,784) and 372nm ( 3,117). [NMR and UV: Matsuda & Aiba Chem Lett 951 1978, Wagner et al. Chem Ber 75 935 1942.]
Check Digit Verification of cas no
The CAS Registry Mumber 68206-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,0 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68206-45:
(7*6)+(6*8)+(5*2)+(4*0)+(3*6)+(2*4)+(1*5)=131
131 % 10 = 1
So 68206-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H3N2O2S/c8-7(9)4-2-1-3-6-5(4)10/h1-3H
68206-45-1Relevant articles and documents
Matsueda,Aiba
, p. 951 (1978)
A new method for the preparation of 3-nitro-2-pyridinesulfenyl chloride and one-pot syntheses of N(α)-tert-butoxycarbonyl-S-3-nitro-2-pyridinesulfenyl derivatives of cysteine and D-penicillamine
Ueki,Honda,Kazama,Katoh
, p. 21 - 22 (2007/10/02)
3-Nitro-2-pyridinesulfenyl chloride was prepared by the reaction of benzyl 3-nitro-2-pyridyl sulfides with sulfuryl chloride. One-pot syntheses of N(α)-tert-butoxycarbonyl-S-3-nitro-2-pyridinesulfenyl derivatives of cysteine and D-penicillamine were accom
