69212-31-3Relevant articles and documents
Xanthates as Thiol Surrogates for Nucleophilic Substitution with Aryl Halides
Sokolov, Anatolii I.,Mikhaylov, Andrey A.,Baleeva, Nadezhda S.,Baranov, Mikhail S.
, p. 4350 - 4357 (2021/08/24)
We herein report an unprecedented xanthate-based protocol for the preparation of aryl-alkyl thioethers. Heating xanthates with aryl halides and namely cesium carbonate in methanol provides the target thioethers in generally good yields within short reaction times. This method allows one to avoid contact with odorous thiols and also to introduce substituents of which the corresponding thiols are virtually unavailable or inconvenient in use.
Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks
Olsen, Frank N.,Tsakos, Michail,Poulsen, Thomas B.
supporting information, p. 2697 - 2701 (2015/11/27)
We report a new and rapid method for side-chain dehydration/dehydrothiolation of serine, threonine, and cysteine building blocks. The method relies on activation with 3-nitro-2-pyridinesulfenyl chloride (Npys-Cl) followed by treatment with base. It is pos
Microwave-promoted "one-Pot" synthesis of 4- nitrobenzylthioinosine analogues using thiourea as a sulfur precursor
Niu, Hong-Ying,Xia, Chao,Qu, Gui-Rong,Wu, Shan,Jiang, Yi,Jin, Xin,Guo, Hai-Ming
supporting information; experimental part, p. 45 - 49 (2012/04/04)
An efficient one-pot method for the synthesis of various C6-alkylthio-substituted purine nucleosides has been developed under microwave irradiation with good to excellent yields without any metal catalyst (see scheme). This process expands the scope of existing synthetic methodologies and was further successfully applied for synthesis of the biologically important compound 4-nitrobenzylthioinosine (NBTI).