68502-20-5

Basic information

• Product Name: N1-ethyl-4-(Methylsulfonyl)benzene-1,2-diaMine
• Synonyms: N1-ethyl-4-(Methylsulfonyl)benzene-1,2-diaMine
• CAS NO: 68502-20-5
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28466
• Mol File: 68502-20-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N1-ethyl-4-(Methylsulfonyl)benzene-1,2-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N1-ethyl-4-(Methylsulfonyl)benzene-1,2-diaMine(68502-20-5)
• EPA Substance Registry System: N1-ethyl-4-(Methylsulfonyl)benzene-1,2-diaMine(68502-20-5)

Safety Data

• Hazardous Substances Data: 68502-20-5(Hazardous Substances Data)

Usage

Description

N1-ethyl-4-(methylsulfonyl)benzene-1,2-diamine is a chemical compound with the molecular formula C10H16N2O2S. It is a diamine derivative characterized by the presence of an ethyl group attached to the nitrogen atom and a methylsulfonyl group attached to the benzene ring.

Uses

Used in Pharmaceutical Industry:
N1-ethyl-4-(methylsulfonyl)benzene-1,2-diamine is used as an intermediate in the production of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties and effectiveness.
Used in Dye Industry:
N1-ethyl-4-(methylsulfonyl)benzene-1,2-diamine is utilized as an intermediate in the synthesis of dyes, contributing to the development of colorants with specific characteristics, such as hue, stability, and solubility.
Used in Polymer Industry:
N1-ethyl-4-(methylsulfonyl)benzene-1,2-diamine serves as a building block in the creation of polymers, playing a role in determining the polymers' properties, such as strength, flexibility, and durability.
Used in Organic Synthesis:
N1-ethyl-4-(methylsulfonyl)benzene-1,2-diamine is employed in the synthesis of other organic compounds, acting as a versatile precursor that can be transformed into a variety of different molecules for diverse applications.

Upstream product

• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 21355-97-5 3-nitro-4-ethylaminophenyl methyl sulfone 

Relevant articles and documents

Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts

Cancer poses a world-wide healthcare problem, demanding selective and effective therapy protocols. To address that, a vast amount of therapeutic candidates are being investigated in the field of medicinal chemistry. Accordingly, indole-benzimidazole structures have recently gained considerable interest because of their anticancer properties and estrogen receptor (ER) modulatory actions. In this study, novel methylsulfonyl indole-benzimidazole derivatives have been synthesized upon substitution of respectively the first (R1) and fifth (R2) positions of benzimidazole and indole groups. Structure and activity relationships were then studied via1H NMR, 13C NMR, mass spectral and in silico docking analyses, as well as cell viability measurements. We found that the compounds exhibited substantial affinity levels towards ER alpha (ERα). In addition, the correlation analysis of cytotoxicity profiles between ethyl- and methyl-sulfonyl indole-benzimidazoles revealed a collection of effective and consistent R1 and R2 substitutions. However, for some candidate derivatives, distinctive cytotoxicity levels and varying viability versus ERα affinity correlations were observable across the studies, suggesting that the sulfonyl side chain modifications themselves can also influence the ERα binding levels. These results demonstrated that our novel methylsulfonyl indole-benzimidazole derivatives, similar to their ethylsulfonyl counterparts, exhibit anticancer effects with potential estrogen receptor modulatory actions. This journal is