68700-92-5

Basic information

• Product Name: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-
• Synonyms: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-;2-CHLORO-5-(1-METHYLETHENYL) PYRIDINE;2-chloro-5-(prop-1-en-2-yl)pyridine
• CAS NO: 68700-92-5
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.61
• Mol File: 68700-92-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 224.178 °C at 760 mmHg
• Flash Point: 110.789 °C
• Appearance: /
• Density: 1.094 g/cm³
• Vapor Pressure: 0.138mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(68700-92-5)
• EPA Substance Registry System: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(68700-92-5)

Safety Data

• Hazardous Substances Data: 68700-92-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-(1-methylethenyl)pyridine is a chemical compound with the molecular formula C9H8ClN. It is a chlorinated derivative of pyridine, a heterocyclic compound commonly used in the production of pesticides, pharmaceuticals, and other organic compounds. This particular derivative contains a chlorine atom and an isopropenyl group attached to the pyridine ring. It is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also known for its strong, unpleasant odor. PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)- is typically handled with care and proper safety measures due to its potential hazards if not used properly.

InChI:InChI=1/C8H8ClN/c1-6(2)7-3-4-8(9)10-5-7/h3-5H,1H2,2H3

Upstream product

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• 126726-62-3 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 68700-91-4 2-chloro-5-(1-hydroxy-1-methylethyl)pyridine 
• 6192-52-5 p-toluenesulfonic acid monohydrate 

Downstream Products

• 68700-93-6 2-chloro-5-isopropylpyridine 

Relevant articles and documents

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.

Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them

Pyrido[2,1-b]quinazolines of the formulas STR1 wherein R1, R1 ', R2, R2 ', R3, R3 ', R4 and R10 are as hereinafter set forth, and processes for the preparation thereof