68882-86-0

Basic information

• Product Name: 6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester
• Synonyms: 6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester;2-Oxo-1,2-dihydro-quinoline-6-carboxylic acid methyl ester;methyl 2-oxo-1,2-dihydroquinoline-6-carboxylate
• CAS NO: 68882-86-0
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19406
• Mol File: 68882-86-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 251-253 °C(Solv: chloroform (67-66-3))
• Boiling Point: 434.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• PKA: 11.11±0.70(Predicted)
• CAS DataBase Reference: 6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(68882-86-0)
• EPA Substance Registry System: 6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester(68882-86-0)

Safety Data

• Hazardous Substances Data: 68882-86-0(Hazardous Substances Data)

Upstream product

• 358368-09-9 1-oxy-quinoline-6-carboxylic acid methyl ester 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 1895-39-2 sodium chlorodifluoroacetate 
• 916486-08-3 4-methoxycarbonyl-2-(trimethylsilylethynyl)aniline 
• 67-56-1 methanol 
• 1810-66-8 6-bromo-2-quinolone 
• 201230-82-2 carbon monoxide 
• 38896-30-9 6-(methoxycarbonyl)quinoline 
• 70639-77-9 1,2,3,4-tetrahydro-2-oxo-6-quinolinecarboxylic acid 
• 177478-63-6 2-oxo-1,2,3,4-tetrahydro-6-quinolinecarboxylic acid methyl ester 
• 10349-57-2 Quinoline-6-carboxylic acid 
• 91-62-3 6-methylquinoline 

Downstream Products

• 849807-09-6 2-chloro-quinoline-6-carboxylic acid methyl ester 
• 1333259-75-8 methyl 2-[1-(4-phenoxyphenoxy)propan-2-yl]oxyquinoline-6-carboxylate 
• 1333259-76-9 2-[1-(4-phenoxyphenoxy)propan-2-yl]oxyquinoline-6-carboxylic acid 
• 70639-78-0 1,2-dihydro-2-oxo-6-quinolinecarboxylic acid 
• 1609389-22-1 N-(2-aminophenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide 
• 70639-78-0 2-hydroxyuinoline-6-carboxylic acid 

Relevant articles and documents

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.

INHIBITORS OF ENL/AF9 YEATS

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

SELECTIVE HDAC1,2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.