690636-28-3

Basic information

• Product Name: 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine
• Synonyms: 4-(2-Morpholinoethoxy)phenylboronic acid, pinacol ester;4-{2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}morpholine, 2-{4-[2-(Morpholin-4-yl)ethoxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-[2-(Morpholin-4-yl)ethoxy]benzeneboronicacid,pinacolester97%
• CAS NO: 690636-28-3
• Molecular Formula: C₁₈H₂₈BNO₄
• Molecular Weight: 333.24
• Product Categories: blocks;BoronicAcids
• Mol File: 690636-28-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 456.7°C at 760 mmHg
• Flash Point: 230°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 1.58E-08mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine(690636-28-3)
• EPA Substance Registry System: 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine(690636-28-3)

Safety Data

• Hazardous Substances Data: 690636-28-3(Hazardous Substances Data)

Usage

General Description

4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine, also known by its trade name Adprosone, is a chemical used as a flame retardant and anti-corrosive agent in various consumer and industrial products. It is a member of the morpholine chemical family and contains the boron element, which gives it its flame-retardant properties. This chemical is used in the production of plastics, polymers, and coatings to improve their resistance to fire and corrosion, making it an important component in industries such as construction, electronics, and automotive. Additionally, 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine has low toxicity and environmental impact, making it a preferred choice for manufacturers looking to produce more sustainable and safe products.

InChI:InChI=1/C18H28BNO4/c1-17(2)18(3,4)24-19(23-17)15-5-7-16(8-6-15)22-14-11-20-9-12-21-13-10-20/h5-8H,9-14H2,1-4H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 836-59-9 1-bromo-4-(2-morpholinoethoxy)benzene 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 55162-34-0 1-bromo-4-(2-chloroethoxy)benzene 
• 106-41-2 4-bromo-phenol 
• 46230-78-8 2-(morpholin-1-yl)ethyl methanesulfonate 
• 269409-70-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 
• 103808-71-5 4-<2-(p-iodophenoxy)ethyl>morpholine 
• 622-40-2 2-(morpholin-4-yl)ethanol 
• 540-38-5 p-Iodophenol 
• 3240-94-6 N-(2-chlorethyl)morpholine 
• 3647-69-6 4-(2-chloroethyl)morpholine hydrochride 

Downstream Products

• 1344700-80-6 (2S)-N-(benzyloxy)-N',2-dimethyl-2-[methyl({4'-[2-(morpholin-4-yl)ethoxy]biphenyl-4-yl}carbonyl)amino]propanediamide 

Relevant articles and documents

Synthesis method of tirbanibulin intermediate

The invention belongs to the technical field of synthesis of medical compounds, and particularly discloses a synthesis method of a tirbanibulin intermediate. According to the method, 4-[2-(4-bromophenoxy)ethyl]morpholine is adopted as a raw material, firstly reacts with an n-butyl magnesium lithium reagent and then reacts with isopropyl alcohol pinacol borate, and the tirbanibulin intermediate is synthesized through a one-pot method. The method is mild in reaction condition and simple to operate, the reaction product is single, the target product can be obtained at high yield through a simple post-treatment and recrystallization method, and the method is expected to be developed into an industrial production method.

IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatographic purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model.