69065-91-4

Basic information

• Product Name: ETHYL 2-(4-FLUOROANILINO)-2-OXOACETATE
• Synonyms: ETHYL 2-(4-FLUOROANILINO)-2-OXOACETATE;Ethyl 2-((4-fluorophenyl)aMino)-2-oxoacetate
• CAS NO: 69065-91-4
• Molecular Formula: C₁₀H₁₀FNO₃
• Molecular Weight: 211.19
• Mol File: 69065-91-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 120-122°C
• Appearance: /
• Density: 1.293 g/cm³
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 2-(4-FLUOROANILINO)-2-OXOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(4-FLUOROANILINO)-2-OXOACETATE(69065-91-4)
• EPA Substance Registry System: ETHYL 2-(4-FLUOROANILINO)-2-OXOACETATE(69065-91-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 69065-91-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(4-Fluoroanilino)-2-oxoacetate is a chemical compound that belongs to the class of organic compounds known as phenylpyruvic acid derivatives. Its molecular formula is C11H11FNO3. It is characterized by the presence of a phenylpyruvic acid, or a derivative thereof, where the phenyl group is substituted at one carbon atom by an amino group. How this compound functions biologically or industrially is not extensively studied or acknowledged in common databases, which probably indicates it is not commonly utilized or that its functions have yet to be discovered. Its physical and chemical properties, safety data, and potential effects on health also remain unreported. This lack of information indicates that further research needs to be conducted to fully understand this compound.

InChI:InChI=1/C10H10FNO3/c1-2-15-10(14)9(13)12-8-5-3-7(11)4-6-8/h3-6H,2H2,1H3,(H,12,13)

Upstream product

• 371-40-4 4-fluoroaniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 69066-43-9 2-((4-fluorophenyl)amino)-2-oxoacetic acid 
• 69066-19-9 (4-Fluoro-phenylamino)-thioxo-acetic acid ethyl ester 
• 896166-18-0 N-(4-fluorophenyl)-N'-(1-phenylcyclopentylmethyl)ethanediamide 
• 1375736-84-7 N¹-(4-fluorophenyl)-N²-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride 
• 1375736-94-9 N¹-(4-fluorophenyl)-N²-((5-(2-hydroxyethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide hydrochloride 
• 1338471-39-8 (S)-5-(2,6-difluorophenoxy)-3-[(4-fluoro-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid 
• 1338471-30-9 (S)-3-[(4-fluoro-phenylaminooxalyl)-amino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid 
• 1338471-27-4 5-fluoro-3-[(4-fluoro-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid 

Relevant articles and documents

PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

Visible light-mediated photocatalytic oxidative cleavage of activated alkynes: Via hydroamination: A direct approach to oxamates

The direct oxidative cleavage of activated alkynes via hydroamination has been described using organic photocatalyst under visible-light irradiation at room temperature. In this reaction, the single electron oxidation of an in situ formed enamine followed by radical coupling with an oxidant finally delivers the oxamate. The key features of this photocatalytic reaction are the mild reaction conditions, metal-free organic dye as a photocatalyst, and TBHP playing a dual role as O source and for the regeneration of the photocatalyst.

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism. Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an analysis of the structure-activity relationships related to metabolic activation and SCD inhibition.