69189-19-1

Basic information

• Product Name: 4-broMo-1,2-bis(broMoMethyl)benzene
• Synonyms: 4-broMo-1,2-bis(broMoMethyl)benzene;Benzene, 4-bromo-1,2-bis(bromomethyl)-;4-bromo-1,2-bromomethylbenzene
• CAS NO: 69189-19-1
• Molecular Formula: C₈H₇Br₃
• Molecular Weight: 342.85318
• EINECS: 200-258-5
• Mol File: 69189-19-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-broMo-1,2-bis(broMoMethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-1,2-bis(broMoMethyl)benzene(69189-19-1)
• EPA Substance Registry System: 4-broMo-1,2-bis(broMoMethyl)benzene(69189-19-1)

Safety Data

• RIDADR: 3261
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 69189-19-1(Hazardous Substances Data)

Usage

General Description

4-bromo-1,2-bis(bromomethyl)benzene is a chemical compound with the molecular formula C8H8Br2. It is a derivative of benzene with two bromomethyl groups attached to the 1 and 2 positions and a bromine atom attached to the 4 position. 4-broMo-1,2-bis(broMoMethyl)benzene is commonly used in organic synthesis as a building block for the production of various materials and pharmaceuticals. It is also used as a reagent in chemical reactions to introduce bromomethyl groups into other molecules. Additionally, it has been studied for its potential anti-cancer and anti-inflammatory properties, making it of interest to the pharmaceutical industry. The compound is a white to off-white crystalline solid and is generally handled with care due to its potential for toxicity and irritancy.

Upstream product

• 86-90-8 4-bromophthalic anhydride 
• 171011-37-3 4-bromo-2-(hydroxymethyl)benzyl alcohol 

Downstream Products

• 64169-34-2 5-bromophthalide 
• 1618090-65-5 tert-butyl 3-((2R)-[[2-[2-[(Z)-N,N'-bis(tert-butoxycarbonyl)carbamimidoyl]isoindolin-5-yl]acetyl]amino]-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]dec-4-yl)ethyl)-2-methoxybenzoate 
• 1618083-61-6 tert-butyl 3-((2R)-2-((isoindolin-5-yl)acetamido)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]dec-4-yl)ethyl)-2-methoxybenzoate 
• 1618083-60-5 tert-butyl 3-((2R)-2-((2-benzyloxycarbonylisoindolin-5-yl)acetamido)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]dec-4-yl)ethyl)-2-methoxybenzoate 
• 1618083-59-2 2-(2-benzyloxycarbonylisoindolin-5-yl)acetic acid 
• 1618083-58-1 benzyl 5-(2-oxoethyl)isoindoline-2-carboxylate 
• 1618083-57-0 benzyl 5-(2,3-dihydroxypropyl)isoindoline-2-carboxylate 
• 1618083-56-9 benzyl 5-allylisoindoline-2-carboxylate 
• 178445-27-7 benzyl 5-bromoisoindoline-2-carboxylate 
• 127168-84-7 5-bromoisoindoline 
• 1609574-36-8 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propan-1-ol 
• 1609574-33-5 methyl 3-[3,4-bis(tert-butoxycarboinylaminoethyl)phenyl]propanoate 
• 1609574-30-2 (E)-methyl 3-[3,4-bis(tert-butoxycarbonylaminoethyl)phenyl]acrylate 
• 1609568-26-4 4-bromo-1,2-bis(1,3-dimethylimidazolin-2-ylideneaminomethyl)benzene 

Relevant articles and documents

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here report the design, synthesis, and evaluation of a broader panel of bis-amidines inspired by pentamidine. The present study both validates the previously observed synergistic activity reported for pentamidine, while further assessing the capacity for structurally similar bis-amidines to also potentiate Gram-positive specific antibiotics against Gram-negative pathogens. Among the bis-amidines prepared, a number of them were found to exhibit synergistic activity greater than pentamidine. These synergists were shown to effectively potentiate the activity of Gram-positive specific antibiotics against multiple Gram-negative pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, including polymyxin- and carbapenem-resistant strains.

Synthesis of 8-bromo-5,12-tetracenequinone and 2-bromotetracene derivatives

A series of bromotetracenequinones 1 and bromotetracenes 2 were prepared from 4-bromophthalic anhydride. The parent tetracenequinone 1a and tetracene 2a were sparingly soluble in organic solvents. In contrast, dipropyl-substituted tetracenequinone 1b and

AMINO ACID COMPOUNDS

[Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to provide a pharmaceutical agent which comprises the compounds as an effective component, in particular to provide a therapeutic and/or prophylactic agent for an autoimmune disease and the like. [Solving Means] Amino acid compounds that are represented by the following Formula (1) are provided