6926-51-8

Basic information

• Product Name: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE;5-(4-METHOXY-PHENYL)-2H-TETRAZOLE
• CAS NO: 6926-51-8
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.18
• Mol File: 6926-51-8.mol
• Article Data: 151

Chemical Properties

• Melting Point: 235-238°C
• Boiling Point: 365.2°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 1.6E-05mmHg at 25°C
• Refractive Index: 1.591
• BRN: 152619
• CAS DataBase Reference: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(6926-51-8)
• EPA Substance Registry System: 5-(4-METHOXYPHENYL)-1H-TETRAZOLE(6926-51-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 6926-51-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 1565, 1984 DOI: 10.1021/jm00378a007Tetrahedron Letters, 38, p. 1257, 1997 DOI: 10.1016/S0040-4039(97)00052-X

InChI:InChI=1/C8H8N4O/c1-13-7-4-2-6(3-5-7)8-9-11-12-10-8/h2-5H,1H3,(H,9,10,11,12)

Upstream product

• 829-48-1 4-methoxy-benzimidic acid ethyl ester 
• 3424-93-9 4-methoxyphenylacetamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 874-90-8 4-methoxybenzonitrile 
• 104-93-8 p-methylanizole 
• 1265831-02-4 1-(4-methoxybenzyl)-5-(4-methoxyphenyl)-1H-tetrazole 
• 767-00-0 4-cyanophenol 
• 5720-07-0 4-methoxyphenylboronic acid 
• 67-68-5 dimethyl sulfoxide 
• 696-62-8 para-iodoanisole 
• 105-13-5 4-Methoxybenzyl alcohol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 624-84-0 formic acid hydrazide 
• 4648-54-8 trimethylsilylazide 

Downstream Products

• 104186-18-7 4-[5-(4-Methoxy-phenyl)-tetrazol-2-ylmethyl]-2,6-dimethyl-phenol 
• 92595-39-6 4-Hydroxy-3-methoxy-5-[5-(4-methoxy-phenyl)-tetrazol-2-ylmethyl]-benzaldehyde 
• 137898-60-3 5-(4-Methoxy-phenyl)-1-trityl-1H-tetrazole 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 91658-53-6 [5-(4-Methoxy-phenyl)-tetrazol-1-yl]-phenyl-methanone 
• 91658-59-2 [5-(4-Methoxy-phenyl)-tetrazol-2-yl]-phenyl-methanone 
• 43131-50-6 methyl 4-(2-methyl-2H-tetrazol-5-yl)phenyl ether 
• 43131-46-0 5-(4-methoxyphenyl)-1-methyl-1H-tetrazole 
• 117594-33-9 N-[1-[5-(4-Methoxy-phenyl)-tetrazol-2-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine 
• 117594-21-5 N-[1-[5-(4-Methoxy-phenyl)-tetrazol-1-yl]-1-phenyl-meth-(Z)-ylidene]-N'-(4-nitro-phenyl)-hydrazine 
• 1394071-86-3 2-[5-(4-methoxyphenyl)-1H-tetrazol-1-yl]acetohydrazide 
• 914221-71-9 2-ethyl-5-(4-methoxyphenyl)-2H-tetrazole 
• 60637-00-5 ethyl 4-(5-phenyl-2H-tetrazol-2-yl)benzoate 

Relevant articles and documents

Synthesis, crystal structure and investigation of the catalytic and spectroscopic properties of a Zn(II) complex with coumarin-hydrazone ligand

A Zn(II) complex with coumarin-hydrazone ligand, [ZnCl(HL)(CH3OH)0.76(H2O)0.24]·0.24(CH3OH) (1), was synthesized from the reaction of equimolar amount of ZnCl2·4H2O and (E)-2-hyd

Oxidation/ MCR domino protocol for direct transformation of methyl benzene, alcohol, and nitro compounds to the corresponding tetrazole using a three-functional redox catalytic system bearing TEMPO/Co(III)-porphyrin/ Ni(II) complex

A redox catalytic system for oxidation-reduction reactions and the domino preparation of tetrazole compounds from nitro and alcohol precursors was designed, prepared and characterized by UV–vis, GPC, TGA, XRD, EDX, XPS, VSM, FE-SEM, TEM, DLS, BET, NMR, and ICP analyses. The catalyst was prepared via several successive steps by demetalation of chlorophyll b, copolymerization with acrylated TEMPO monomers, complexation with Ni and Co metals (In two different steps), then immobilized on magnetic nanoparticles. The presence of three functional groups including TEMPO, coordinated cobalt, and coordinated nickel in the catalyst, allowed the oxidation of various types of alcohols, alkyl benzenes as well as the reduction of nitro compounds by a single catalyst. All reactions yielded up to 97 % selectivity for oxidation and reduction reactions. Next, the ability of the catalyst to successfully convert alcohol, methyl benzenes and nitro to their corresponding tetrazoles was studied.

Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures. The synthetic protocol involves two-component reaction between aryl nitriles and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2 + 3] cycloaddition, short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.