692771-01-0Relevant articles and documents
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives
Pibiri, Ivana,Lentini, Laura,Melfi, Raffaella,Gallucci, Giulia,Pace, Andrea,Spinello, Angelo,Barone, Giampaolo,Di Leonardo, Aldo
, p. 236 - 244 (2015)
Abstract Premature stop codons are the result of nonsense mutations occurring within the coding sequence of a gene. These mutations lead to the synthesis of a truncated protein and are responsible for several genetic diseases. A potential pharmacological
NBS-mediated practical cyclization of N-acyl amidines to 1,2,4-oxadiazoles via oxidative N?O bond formation
Li, Ertong,Wang, Manman,Wang, Zhen,Yu, Wenquan,Chang, Junbiao
, p. 4613 - 4618 (2018/07/31)
A reaction involving an efficient NBS-mediated oxidative N?O bond formation has been established for the synthesis of 1,2,4-oxadiazoles from readily accessible N-acyl amidines. The features of this synthetic method include simplicity of operation, mild re
Copper-catalyzed direct synthesis of 1,2,4-oxadiazoles from amides and organic nitriles by oxidative N-O bond formation
Kuram, Malleswara Rao,Kim, Woo Gyum,Myung, Kyungjae,Hong, Sung You
supporting information, p. 438 - 442 (2016/02/19)
Herein, we report the first Cu-catalyzed one-step method for the synthesis of 1,2,4-oxadiazoles from stable, less toxic, and readily available amides and organic nitriles by a rare oxidative N-O bond formation using O2 as sole oxidant. This met
