69374-79-4

Basic information

• Product Name: 2-(4-BroMo-phenyl)-2-oxo-acetaMide
• Synonyms: 2-(4-BroMo-phenyl)-2-oxo-acetaMide;BenzeneacetaMide,4-broMo-α-oxo-
• CAS NO: 69374-79-4
• Molecular Formula: C₈H₆BrNO₂
• Molecular Weight: 228.04274
• Mol File: 69374-79-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-BroMo-phenyl)-2-oxo-acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BroMo-phenyl)-2-oxo-acetaMide(69374-79-4)
• EPA Substance Registry System: 2-(4-BroMo-phenyl)-2-oxo-acetaMide(69374-79-4)

Safety Data

• Hazardous Substances Data: 69374-79-4(Hazardous Substances Data)

Usage

General Description

The chemical 2-(4-Bromo-phenyl)-2-oxo-acetamide, also known as 4-bromo-benzoylacetamide, is an organic compound with the molecular formula C9H8BrNO2. It is a white to yellow crystalline powder that is soluble in organic solvents. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has various applications in the field of medicinal chemistry and drug development, particularly as a building block to create new compounds with potential biological activities. Additionally, this compound has been studied for its potential antifungal and antibacterial properties. Overall, 2-(4-Bromo-phenyl)-2-oxo-acetamide is an important and versatile chemical with diverse applications in various industries.

Upstream product

• 4203-30-9 1-(4-bromo-phenyl)-2-diazo-ethanone 
• 16532-79-9 4-Bromophenylacetonitrile 
• 51627-99-7 ethyl 2-(4-bromophenyl)acetimidate hydrochloride 
• 99-90-1 para-bromoacetophenone 
• 62551-73-9 2-oxo-2-(4-bromophenyl)acetyl chloride 
• 6048-21-1 4-bromobenzoyl cyanide 

Downstream Products

• 393531-26-5 (R)-2-(4-bromophenyl)-2-hydroxyacetamide 
• 144664-12-0 (S)-2-(4-bromophenyl)-2-hydroxyacetamide 
• 7099-87-8 4-bromophenylglyoxylic acid 

Relevant articles and documents

Oxidative Coupling of Diazo and NH4I: A Route to Primary Oxamates and α-Ketoamides

A simple and efficient method has been developed for the preparation of primary oxamates and α-ketoamides through the oxidative coupling of diazo compounds and NH4I. Under the optimized reaction conditions, a range of diazoesters and α-diazoketones was explored, and the corresponding products were obtained in moderate to good yields. This protocol is metal-free, is performed under mild conditions, has a wide substrate scope, and offers operational simplicity.

Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides

A simple and straightforward method for the synthesis of primary α-ketoamides has been discovered. The reaction represents the first example of benzylimidates directly converting to primary α-ketoamides by using sustainable molecular oxygen as an oxidant. This reaction proceeds in the presence of copper(II) salt via cleavage of benzylic C-H and C-O bonds of the benzylimidates with liberation of alcohols as the only byproduct. A wide substrate scope, operationally mild conditions, the use of single substrates, and a reaction scaled up to grams make this strategy very attractive and practical. Furthermore, mechanistic studies illustrate that the imidate group adjacent to the benzylic position plays crucial role in facilitating this chemical process.

A novel approach for the one-pot preparation of α-ketoamides by anodic oxidation

The direct oxidative synthesis of α-ketoamides via anodic oxidation was developed by using dioxygen as a reactant under mild conditions. This methodology has a broad substrate scope (aromatic amines, aliphatic amines and ammonium acetate) and opens up an interesting and attractive avenue for the synthesis of α-ketoamide derivatives.