693811-18-6Relevant articles and documents
PROTEIN-POLYMER-DRUG CONJUGATES
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Paragraph 0951; 0952, (2015/04/21)
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conj
Chemotherapeutic bone-targeted bisphosphonate prodrugs with hydrolytic mode of activation
Erez, Rotem,Ebner, Sharon,Attali, Bernard,Shabat, Doron
, p. 816 - 820 (2008/09/16)
Osseous tissues are considered to be limited as therapeutic target sites due to their biological properties. We have designed and synthesized two kinds of hydrolytically activated chemotherapeutic prodrugs containing bisphosphonate, a bone-targeting moiet