69395-13-7Relevant articles and documents
Epoxide Electroreduction
Huang, Cheng,Lu, Qingquan,Ma, Wan,Qi, Xiaotian,Xu, Minghao,Zheng, Xuelian
, p. 1389 - 1395 (2022/01/19)
Selective hydrogenation of epoxides would be a direct and powerful approach for alcohol synthesis, but it has proven to be elusive. Here, electrochemically epoxide hydrogenation using electrons and protons as reductants is reported. A wide range of primary, secondary, and tertiary alcohols can be achieved through selective Markovnikov or anti-Markovnikov ring opening in the absence of transition metals. Mechanistic investigations revealed that the regioselectivity is controlled by the thermodynamic stabilities of the in situ generated benzyl radicals for aryl-substituted epoxides and the kinetic tendency for Markovnikov selective ring opening for alkyl-substituted epoxides.
Selective A2A receptor antagonist
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, (2018/12/14)
The invention provides a selective A2A receptor antagonist. In specific, the invention provides the selective A2A receptor antagonist shown in the formula (I), a drug composition containing the same and the pharmacy application and treatment application t
Indole derivatives and pharmaceutical composition comprising the same for treating or preventing disease related to RAGE
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Paragraph 0635-0640, (2021/10/25)
A novel indole-based derivative acceptable salt, and manufacturing method thereof including RAGE associated pharmaceutical composition for the prevention or the treatment of disorders the disclosure. Herein a derivative indole-based according to by antagonism in RAGE, nerve cells with the Amyloid-beta peptide loses purpose: a method of fabricating a apparatus move into brain, Alzheimer's disease associated RAGE disease, cerebrovascular dementia, dementia due to damage bean curd, multi blockade dementia, Alzheimer's disease or the like dementia alcoholic or mixed dementia multi blockade and including dementia, pick (pick) bottle, a smartcrew [...] -Jakob (Creutzfeldt-jakob) bottle, that thyroid gland symptoms , bean curd a blade Parkinson (Parkinson) bottle, Huntington's disease (Huntington) which is useful in preventing or treating, can be used.