69410-45-3Relevant articles and documents
SMALL MOLECULE ANTAGONIST COMPOUND TAC5 SERIES HAVING TOLL-LIKE RECEPTOR 3/7/8/9 INHIBITORY FUNCTION
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, (2021/07/17)
A small molecule antagonist compound having a toll-like receptor 3/7/8/9 inhibitory function and its use in inhibiting TLR7, TLR8, TLR9 and TLR3 are disclosed. A novel compound expressed by TAC5 and TAC5-a, TAC5-c, TAC5-d or TAC5-e which are derivatives thereof not only prevents TNFα secretion, NFkB activation, IkB degradation and MAPKs phosphorylation induced by poly(I:C) (TLR3 agonist), IMQ (TLR7 agonist), CL075 (TLR7/8 agonist), R848 (TLR7/8 agonist), TL8 (TLR8 agonist) or CpG ODN (TLR9 agonist), but also inhibits generation of inflammatory cytokine, and thus is highly advantageous for preventive or therapeutic use for TLR3/7/8/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus, psoriasis and the like.
Phenyl acetamides as sPLA2 inhibitors
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Page column 15, (2008/06/13)
A class of novel phenyl acetamides is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.
Biscyclophanes. Part 2: Regioselectivity in the Acid-catalysed Cycloalkylation of Benzylbenzylic Alcohol (BBA)
Lee, Woo Young,Sim, Wonbo,Kim, Hyo-Joong,Yoon, Sung-Hwa
, p. 719 - 730 (2007/10/02)
o-Benzylbenzylic alcohols (o-BBAs), in which the terminnal benzyl alcohol is substituted by repeating benzyl chains all in the ortho sense, have been found to have conspicuous regioselectivity in acid-catalysed cycloalkylation, giving rise to various cycl