630-25-1

Basic information

• Product Name: 1,2-DIBROMOTETRACHLOROETHANE
• Synonyms: 1,1,2,2-Tetrachloro-1,2-dibromoethane;1,2-Dibromotetrachloroethane,97%;1,2-DibroMotetrachloroethane, 97% 25GR;1,2-DIBROMOTETRACHLOROETHANE FOR SYNTHES;1,2-DibroMotetrachloroethane 97%;1,2-dibromo-1,1,2,2-tetrachloro-ethan;Dbtce;Ethane, 1,2-dibromo-1,1,2,2-tetrachloro-
• CAS NO: 630-25-1
• Molecular Formula: C₂Br₂Cl₄
• Molecular Weight: 325.64
• EINECS: 211-136-7
• Product Categories: Ethanes/ethenes;Bromination;Halogenation;Synthetic Organic Chemistry;Alkyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 630-25-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 215-220 °C (dec.)(lit.)
• Boiling Point: 219℃
• Flash Point: 105℃
• Appearance: White to beige/Crystalline Powder, Crystals and/or Chunks
• Density: 2.713 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.18mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: Store below +30°C.
• Water Solubility: Insoluble in water.
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 1699471
• CAS DataBase Reference: 1,2-DIBROMOTETRACHLOROETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIBROMOTETRACHLOROETHANE(630-25-1)
• EPA Substance Registry System: 1,2-DIBROMOTETRACHLOROETHANE(630-25-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: KH9366000
• Hazardous Substances Data: 630-25-1(Hazardous Substances Data)

Usage

Chemical Properties

colourless solid

Uses

Different sources of media describe the Uses of 630-25-1 differently. You can refer to the following data:
1. 1,2-dibromotetrachloroethane is used as a fire-proofing agent. It is actively involved in the conversion of sulfones to alkenes by Ramberg-Backlund rearrangement. It is an effective replacement for ozone depleting solvents like dibromodifluoromethane and tetrabromodifluoroethane. It is also utilized as a brominating reagent. In analytical chemistry, it is used in quantitative determination of perhalogenated compounds by high-performance liquid chromatography (HPLC).
2. 1,2-Dibromotetrachloroethane is used as halogenating reagent for the one-pot conversion of sulfones to alkenes by Ramberg-B?cklund rearrangement. It is a useful brominating reagent for diaryl TeII species.
3. 1,2-Dibromotetrachloroethane was used in quantitative determination of perhalogenated compounds by HPLC.

General Description

1,2-Dibromotetrachloroethane acts as halogenating reagent for the one-pot conversion of sulfones to alkenes by Ramberg-B?cklund rearrangement. It is a useful brominating reagent for diaryl TeII species.

InChI:InChI=1/C2Br2Cl4/c3-1(5,6)2(4,7)8

Synthetic route

1,1,2,2-tetrachloroethylene (127-18-4) → 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1)

Conditions	Yield
With bromine for 2h; Irradiation;	94%
With bromine In dichloromethane for 72h; Heating;	85%
With bromine photochemische Bildung;
With bromine Geschwindigkeit der Bildung;

pentachloroethane (76-01-7) → 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1)

Conditions	Yield
With aluminium trichloride; bromine at 70℃;

C2Cl4 → 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1)

Conditions	Yield
With bromine im Sonnenlicht;

dibromodichloromethane (594-18-3) → tetrachloromethane (56-23-5) + 1,1,2,2-tetrachloroethylene (127-18-4) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + Bromotrichloromethane (75-62-7) + bromine (7726-95-6)

Conditions	Yield
In neat (no solvent) Kinetics; other Radiation; γ-radiolysis at -196 and 131°C;;

[(bis(1-methylethyl)amino)carbonyl]ferrocene (169830-46-0) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → (pR)-2-bromo-(N,N-diisopropyl)ferrocenecarboxamide (937184-52-6)

Conditions

Yield

With (-)-sparteine; n-butyllithium In diethyl ether under Ar atm. to soln. (-)-sparteine in Et2O at -78°C n-BuLi was added over 30 min, stirred for 1.5 h, soln. BrCCl2CCl2Br in Et2O was added over 20 min, stirred for 1 h and allowed to warm to room temp.; react. mixt. was quenched with aq. NH4Cl, extd. with Et2O, washed with water and brine, dried, filtered, and evapd., chromy. on silica (hexane-EtOAc 9:1); elem. anal.;

99%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + bis[μ-[(η5-(S,Rp)-2-(4′-isopropyl-4′,5′-dihydro-2′-oxazolyl-κN)-3-methyl-cyclopentadienyl-κC)(η5-cyclopentadienyl)ferrocene]]digold(I) → dibromobis[μ-[(η5-(S,Rp)-2-(4′-isopropyl-4′,5′-dihydro-2′-oxazolyl-κN)-3-methyl-cyclopentadienyl-κC)(η5-cyclopentadienyl)ferrocene]]digold(II)

Conditions	Yield
In dichloromethane at 20℃; for 0.5h; Inert atmosphere;	98%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + 4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran] → 2-bromo-4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran]

Conditions	Yield
Stage #1: 4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran] With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Schlenk technique; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at -78 - 20℃; Schlenk technique; Inert atmosphere;	96%

N-(2-fluoro-5-pyridyl)cyclopropane carboxamide (112959-64-5) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → N-(2-fluoro-5-pyridyl)-cyclopropylmethanimidoyl bromide

Conditions	Yield
With triethylamine; triphenylphosphine In 1,2-dichloro-ethane	95%

ferrocene (102-54-5) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → bromoferrocene (1273-73-0)

Conditions	Yield
With potassium tert-butoxide; t-butyl lithium In tetrahydrofuran; hexane Schlenk techniques used under N2 or Ar, THF soln. of FcH (10.8 mmol) andtBuOK(1.34 mmol) cooled to -78°C, after >15 min tBuLi soln.(21.6 mmol) dropwise added, stirred for 1.5 h at <-70°C, C2Cl4Br2 adde d, stirred for 30 min at -78°C; allowed to warm to room temp., quenched with H2O, extracted with CH2Cl2,organic layer washed with H2O, dried over MgSO4, solvent removed under vac., chromd. (neutral alumina, hexane); NMR;	95%
Stage #1: ferrocene With potassium tert-butylate; tert.-butyl lithium In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;	88%
Stage #1: ferrocene With potassium tert-butylate; tert.-butyl lithium In tetrahydrofuran; hexane at -78℃; for 1.5h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at -78℃; for 0.5h;	80%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + 4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran] → 2,2'-dibromo-4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran]

Conditions	Yield
Stage #1: 4,4',5,5'-tetrahydro-7,7'-spirobi[thieno[2,3-c]pyran] With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Schlenk technique; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at -78 - 20℃; Schlenk technique; Inert atmosphere;	95%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → 4,5-dibromonicotinic acid (1009334-28-4)

Conditions	Yield
Stage #1: 5-bromo-3-pyridinecarboxylic acid With lithium diisopropyl amide In tetrahydrofuran at -70 - -55℃; for 3.5h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -70 - -20℃; for 2.5h;	93%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + trans-[FeC5H4CH(CH3)CH2CHN(CH3)2C5H4] → Br(C5H3)Fe(C5H4)CH(CH3)CH2CH(N(CH3)2)

Conditions	Yield
With tBuLi In diethyl ether tBuLi, Et2O, 0°C; Cl2BrC2BrCl2, Et2O, -78°C;	93%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + C14H20O3 → C14H19BrO3 + C14H18Br2O3

Conditions	Yield
Stage #1: C14H20O3 With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -55 - 20℃; for 0.75h; Inert atmosphere;	A 90% B 1.7%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + 4,5-Diiodo-1-ethoxymethyl-2-methylimidazole (273408-63-2) → 5-bromo-1-(ethoxymethyl)-4-iodo-2-methyl-1H-imidazole (273408-64-3)

Conditions	Yield
Stage #1: 4,5-Diiodo-1-ethoxymethyl-2-methylimidazole With isopropylmagnesium bromide In tetrahydrofuran at -40℃; for 1.5h; Grignard reaction; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -40 - 20℃; Substitution; Further stages.;	85%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + 3-(4-tert-butylphenyl)propan-1-ol (78574-08-0) → 4-(3-bromopropyl)-1-(1,1-dimethylethyl)benzene (141499-24-3)

Conditions	Yield
With triethylamine; triphenylphosphine In dichloromethane; 1,2-dichloro-ethane	85%

6-chlorobenzo[b]thiophene (66490-20-8) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → 2-bromo-6-chlorobenzo[b]thiophene (1322718-91-1)

Conditions	Yield
Stage #1: 6-chlorobenzo[b]thiophene With (2-methylpropyl)lithium In diethyl ether; cyclohexane at -78℃; for 1.25h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In diethyl ether; cyclohexane at 20℃; for 16h;	85%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + (R,R)-1,1'-bis(α-N,N-dimethylaminopropyl)ferrocene → (R,R,pS,pS)-2,2'-bis(α-N,N-dimethylaminopropyl)-1,1'-dibromoferrocene

Conditions

Yield

With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2, to a soln. of Fe compd. (diethyl ether) added dropwise a soln. of Licompd. (hexane) (15 min, room temp.), after overnight cooled (acetone/d ry ice), a soln. of Br compd. (THF) added dropwise (15 min), warmed (room temp., 90 min), stirred for 1 h; quenched (satrd. Na2S2O3) at 0°C, diluted (diethyl ether), phasesseparated, extrd. (diethyl ether), org. phases dried (MgSO4), concd. (v ac.), chromy. (silica gel, ethylacetate/hexane); elem. anal.;

84%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + phenyl(thiophen-2-yl)(2,4,6-tri-tert-butylphenyl)borane → (5-bromothiophen-2-yl)(phenyl)(2,4,6-tri-tert-butylphenyl)-borane

Conditions	Yield
Stage #1: phenyl(thiophen-2-yl)(2,4,6-tri-tert-butylphenyl)borane With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.16667h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -78 - 20℃; for 2.08333h;	83%

2,4-Bis(methylthio)pyrimidine (5909-26-2) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → 4-bromo-2,6-bis(methylthio)pyrimidine (1080662-17-4)

Conditions	Yield
Stage #1: 2,4-Bis(methylthio)pyrimidine With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex In tetrahydrofuran at -20℃; for 1h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran at -20℃; for 1h; Inert atmosphere; regioselective reaction;	81%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + C14H11NOS (1450818-55-9) → 3-bromo-2-phenyl-2,1-benzothiazine 2-oxide (1450818-65-1)

Conditions	Yield
Stage #1: C14H11NOS With n-butyllithium In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran Inert atmosphere;	81%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → CFC-112a (76-12-0)

Conditions	Yield
With chlorine monofluoride In 1,1,2-Trichloro-1,2,2-trifluoroethane	80%

ethyl 3-(N,N,N',N'-tetramethyldiamidophosphoryloxy)benzoate (501649-30-5) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → ethyl 3-{[bis(dimethylamino)phosphoryl]oxy}-4-bromobenzoate (1019334-15-6)

Conditions	Yield
Stage #1: ethyl 3-(N,N,N',N'-tetramethyldiamidophosphoryloxy)benzoate With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex at 0℃; for 1h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane	80%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + naphtho[1,2-b:5,6-b′]dithiophene (217-19-6) → 2-bromonaphtho[1,2-b:5,6-b']dithiophene

Conditions	Yield
Stage #1: naphtho[1,2-b:5,6-b′]dithiophene With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 1h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at 25℃; for 18h;	78%

n-butyllithium (109-72-8, 29786-93-4) + (pyridine-2-yl)-1H-ferrocene + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → 1-bromo-2-(2-pyridyl)ferrocene (32913-77-2) + (C5H4Br)Fe(C5H3BrC5H4N) + (C5H5)Fe(C5H3BrC5H3N(C4H9)) + (C5H4Br)Fe(C5H3BrC5H3N(C4H9))

Conditions	Yield
In diethyl ether Ar; n-BuLi (5.3 mmol) added dropwise to Et2O soln. of Fe compd. (1.9 mmol), mixt. stirred for 1 h, cooled to -78°C, ligand (4.6 mmol) added, warmed, stirred for 3 h at room temp.; evapd., chromd. (Al2O3, hexane, hexane/CHCl3, CHCl3), recrystd. (hexane/Et2O), elem. anal.;	A 77% B n/a C n/a D n/a

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + 3-iodophenyl N,N,N',N'-tetramethyldiamidophosphate (1019334-05-4) → 2-bromo-5-iodophenyl N,N,N',N'-tetramethyldiamidophosphate (1019334-19-0)

Conditions	Yield
Stage #1: 3-iodophenyl N,N,N',N'-tetramethyldiamidophosphate With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex at 0℃; for 0.5h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane	76%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + (R,R)-1,1’-bis(α-N,N-dimethylaminoethyl)ferrocene → (R,R,Sp,Sp)-2,2’-bis(α-N,N-dimethylaminoethyl)-1,1’-dibromoferrocene

Conditions	Yield
Stage #1: (R,R)-1,1’-bis(α-N,N-dimethylaminoethyl)ferrocene With n-butyllithium In diethyl ether; hexane at -78 - 20℃; for 16.25h; Glovebox; Schlenk technique; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; diethyl ether; hexane at 20℃; for 2.75h; Glovebox; Schlenk technique; Inert atmosphere; stereospecific reaction;	76%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + Ethyl 2-bromopropionate (535-11-5, 41978-69-2) → ethyl 2,2-dibromopropanoate (34757-17-0)

Conditions	Yield
Stage #1: Ethyl 2-bromopropionate With lithium diisopropyl amide In tetrahydrofuran; hexane at -71℃; for 0.866667h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at -71℃; for 0.666667h; Inert atmosphere;	75%

bis(η5-cyclopentadienyl)ruthenium (1287-13-4) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → 1,1’‑dibromoruthencene (101178-14-7)

Conditions	Yield
Stage #1: bis(η5-cyclopentadienyl)ruthenium With n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine In hexane at 20℃; for 24h; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In hexane at -78 - 20℃;	72%

(4,4'-di-tert-butyl-2,2'-bipyridine)dimethylplatinum(II) + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) → dichloro(4,4'-di-tert-butyl-2,2'-bipyridine)platinum(II) (138736-35-3) + [PtClBrMe2(4,4'-di-tert-butyl-2,2'-bipyridine)] (1209486-48-5)

Conditions	Yield
In acetone to soln. of complex PtMe2(4,4'-di-tert-butyl-2,2'-bipyridine) in acetoneadded (CBrCl2)2 (mol ratio 2:1); ppt. filtered off and crystd. from aceton/pentane; compds. sepd. by crystn.; detn. by NMR;	A n/a B 70%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + naphtho[1,2-b:5,6-b′]dithiophene (217-19-6) → 2,7-dibromonaphtho[1,2-b:5,6-b']dithiophene (1227743-73-8)

Conditions	Yield
Stage #1: naphtho[1,2-b:5,6-b′]dithiophene With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 1h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; hexane at 25℃; for 18h;	63%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + tert-butyl 3,3-dimethyl-3,4-dihydrobenzo[e][1,3]azasiline-1(2H)-carboxylate (1370735-26-4) → tert-butyl 2-hydroxy-3,3-dimethyl-3,4-dihydrobenzo[e][1,3]azasiline-1(2H)-carboxylate

Conditions	Yield
Stage #1: tert-butyl 3,3-dimethyl-3,4-dihydrobenzo[e][1,3]azasiline-1(2H)-carboxylate With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78 - -68℃; for 0.75h; Inert atmosphere; Stage #2: 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; cyclohexane at -78 - -20℃; for 1h;	63%

1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + Phenylselenyl bromide (34837-55-3) + tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidine-1-carboxylate (185303-76-8) → (5R)-3-Bromo-5-(tert-butyl-dimethylsilanyloxymethyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

Conditions	Yield
With ammonium chloride; dihydrogen peroxide; lithium hexamethyldisilazane In tetrahydrofuran; diethyl ether; dichloromethane; water	59%

2-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester + 1,2-dibromo-1,1,2,2-tetrachloroethane (630-25-1) + Phenylselenyl bromide (34837-55-3) → (5R)-3-Bromo-5-(tert-butyl-dimethylsilanyloxymethyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

Conditions	Yield
With ammonium chloride; dihydrogen peroxide; lithium hexamethyldisilazane In tetrahydrofuran; diethyl ether; dichloromethane; water	59%

Upstream product

• 594-18-3 dibromodichloromethane 
• 76-01-7 pentachloroethane 
• 127-18-4 1,1,2,2-tetrachloroethylene 

Downstream Products

• 127-18-4 1,1,2,2-tetrachloroethylene 
• 76-12-0 CFC-112a 
• 7726-95-6 bromine 
• 170108-04-0 2-bromo-3-chloro4-fluorobenzoic acid 
• 36667-05-7 2,3,4-tribromo-benzoic acid 
• 7778-01-0 3,5-dichlorobenzyl bromide 
• 3140-93-0 2,3-dibromothiophen 
• 1003-09-4 2-bromothiophene 
• 34757-17-0 ethyl 2,2-dibromopropanoate 
• 1616388-02-3 tert-butyl N-[1-(benzenesulfonyl)-2-bromopyrrolo[2,3-b]pyridin-5-yl]carbamate 
• 1450818-65-1 3-bromo-2-phenyl-2,1-benzothiazine 2-oxide 
• 784150-40-9 6-bromo-4-chloro-7-(benzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 1351093-96-3 5,6-dibromo-4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1019334-19-0 2-bromo-5-iodophenyl N,N,N',N'-tetramethyldiamidophosphate 

Relevant articles and documents

1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction

An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine (PPh 3) /1,2-dibromotetrachloroethane (DBTCE) complex in excellent yields and very short time (5 min). This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh 3 /DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.