69561-06-4Relevant articles and documents
An Efficient Method for Preparation of 3,5-Diamino-6-chloropyrazin-2-yl Alkyl Ketones Using a Novel Acetylene Hydration Method
Chapdelaine, Marc J.,Warwick, Paul J.,Shaw, Andrew
, p. 1218 - 1221 (1989)
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Auto-tandem catalysis: Synthesis of acridines by Pd-catalyzed C=C bond formation and C(sp2)-N cross-coupling
Huang, Zhongxing,Yang, Yang,Xiao, Qing,Zhang, Yan,Wang, Jianbo
supporting information, p. 6586 - 6593 (2013/01/15)
A facile palladium-catalyzed synthesis of acridines has been realized by consecutive C=C double bond formation and C-N cross-coupling. A variety of functionalized acridines can be accessed from easily available o-dihalobenzenes and N-tosylhydrazones in a single operation. This one-pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine derivatives, which are generally difficult to synthesize by previously known methods.
Reactivity of trihexyl(tetradecyl)phosphonium chloride, a room-temperature phosphonium ionic liquid
Tseng, Ming-Chung,Kan, Huang-Chuan,Chu, Yen-Ho
, p. 9085 - 9089 (2008/09/16)
Trihexyl(tetradecyl)phosphonium chloride 1, a room-temperature ionic liquid, readily undergoes deuterium isotope exchange reaction in deuterated solvents. Under basic conditions, ionic liquid 1 was reactive and 50% deuterium exchanged on all four P-CH2 methylene groups in 9 h at ambient temperature, 30 min at 50 °C, or 12 min at 65 °C. In addition, ionic liquid 1 reacted with sodium salts of substituted benzoates apparently through the direct SN2 carboxylate alkylation to form esters 2 and the resulting esters further converted, via Wittig reaction, to finally afford aryl ketones 4.
