69646-14-6

Basic information

• Product Name: DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE
• Synonyms: AURORA KA-1488;DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE;Diethyl(2-hydroxyphenyl)phosphonate, 95 %;2-diethoxyphosphorylphenol
• CAS NO: 69646-14-6
• Molecular Formula: C₁₀H₁₅O₄P
• Molecular Weight: 230.2
• Mol File: 69646-14-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 322.2 °C at 760 mmHg
• Flash Point: 148.6 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.000151mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE(69646-14-6)
• EPA Substance Registry System: DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE(69646-14-6)

Safety Data

• Hazardous Substances Data: 69646-14-6(Hazardous Substances Data)

Usage

General Description

DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE is an organophosphate compound that is commonly used as a flame retardant in various industrial and consumer products. It is also used as a plasticizer and as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical has been found to exhibit toxic effects on the nervous system and can potentially cause harm to the environment. Furthermore, it has been identified as a potential endocrine disruptor, raising concerns about its impact on human health and the ecosystem. Due to its potential hazards, proper handling, storage, and disposal of DIETHYL(2-HYDROXYPHENYL)PHOSPHONATE are necessary to minimize its environmental and health risks.

InChI:InChI=1/C10H15O4P/c1-3-13-15(12,14-4-2)10-8-6-5-7-9(10)11/h5-8,11H,3-4H2,1-2H3

Upstream product

• 2510-86-3 O,O-diethyl O-phenyl phosphate 
• 16462-86-5 2-(chlorophenyl) diethylphosphate 
• 108-95-2 phenol 
• 762-04-9 phosphonic acid diethyl ester 
• 824-91-9 O-methoxymethylphenol 
• 16462-84-3 diethyl(2-iodophenyl)phosphate 
• 124551-12-8 2-(methoxymethoxy)phenylphosphonic acid diethyl ester 
• 16462-85-4 2-bromophenyl diethyl phosphate 
• 533-58-4 2-Iodophenol 
• 598-02-7 Diethyl phosphate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 91633-07-7 Diethyl 2-(diethoxyphosphinyl)phenyl phosphate 
• 135979-78-1 2-(Diisobutyl-phosphinoyl)-phenol 
• 135979-80-5 2-(Dihexyl-phosphinoyl)-phenol 
• 60253-98-7 o-Hydroxyphenyl-diaethylphosphinoxid 
• 129529-22-2 2-(Dipropyl-phosphinoyl)-phenol 
• 135979-81-6 2-(Dioctyl-phosphinoyl)-phenol 
• 135979-79-2 (2-hydroxyphenyl)dipentylphosphine oxide 
• 69646-17-9 o-hydroxyphenylphosphine 
• 53104-46-4 2-hydroxybenzenephosphonic acid 
• 125727-35-7 sodium o-diethoxyphosphinylphenolate 
• 1335044-31-9 C₁₄H₁₄F₉O₆PS 
• 53839-05-7 o-anisylphosphonic dichloride 
• 124629-83-0 o-dibutylphosphinoylphenol 

Relevant articles and documents

Enantioselective and Regioselective Hydroetherification of Alkynes by Gold-Catalyzed Desymmetrization of Prochiral Phenols with P-Stereogenic Centers

The gold(I)-catalyzed enantioselective hydroetherification of alkynes was achieved via desymmetrization of prochiral bisphenols bearing P-stereogenic centers. (S)-DTBM-Segphos(AuCl)2/AgNTf2 proved to be a highly efficient catalyst system for this transformation, affording P-chiral cyclic phosphine oxides in good yields with high enantioselectivities (with up to 99% ee). The same catalyst system allowed for the enantioselective desymmetrization of dialkynes. Synthetic transformations of the cyclization products afforded other P-chiral molecules with high enantiospecificity.

Insertion of Arynes into P-O Bonds: One-Step Simultaneous Construction of C-P and C-O Bonds

The insertion of arynes into P-O bonds for the preparation of o-hydroxy-substituted arylphosphine oxides, -phosphinates, and -phosphonates is described. This novel reaction leads to the simultaneous formation of C-P and C-O bonds in one step with good yie

Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizing CEase inhibitors. In the present study, we prepared forty-five isocoumarin phosphorus analogues (i.e., phosphaisocoumarins) and investigated the inhibition of these compounds on the CEase. The results showed that some phosphaisocoumarins could act as potent inhibitors of CEase. The most potent inhibitors, compounds 9d, 10a and 12e give IC50 values of 4.8?μM, 2.3?μM and 1.9?μM, respectively. The inhibition mechanism and kinetic characterization studies indicate that they are reversible competitive inhibitors.