6966-21-8

Basic information

• Product Name: NSC 18751
• Synonyms: 1-(4-Hydroxyphenyl)-2-phenyl-1-butanone;4-Hydroxy-2'-phenylbutyrophenone;NSC 18751
• CAS NO: 6966-21-8
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.29704
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6966-21-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 410.8°Cat760mmHg
• Flash Point: 175.4°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 2.47E-07mmHg at 25°C
• Refractive Index: 1.587
• Solubility: Acetone, DIchloromethane
• CAS DataBase Reference: NSC 18751(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 18751(6966-21-8)
• EPA Substance Registry System: NSC 18751(6966-21-8)

Safety Data

• Hazardous Substances Data: 6966-21-8(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

An intermediate for the synthesis of Tamoxifen

InChI:InChI=1/C16H16O2/c1-2-15(12-6-4-3-5-7-12)16(18)13-8-10-14(17)11-9-13/h3-11,15,17H,2H2,1H3

Upstream product

• 78423-10-6 1-(4-methoxyphenyl)-2-phenylbutan-1-one 
• 100-66-3 methoxybenzene 
• 90-27-7 2-Phenylbutyric acid 
• 14293-14-2 4-(benzyloxy)phenyl benzyl ketone 
• 2491-32-9 1-(4-Hydroxyphenyl)-2-phenylethanone 
• 70354-03-9 1-(4-benzyloxyphenyl)-2-phenyl-butan-1-one 

Downstream Products

• 1189368-81-7 C₃₆H₄₄O₄Si 
• 1189368-80-6 C₂₂H₃₀O₂Si 
• 70354-02-8 1-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-phenylbutan-1-one 
• 749-86-0 {2-[4-((Z)-1,2-Diphenyl-but-1-enyl)-phenoxy]-ethyl}-diethyl-amine 
• 10540-29-1 tamoxifen 
• 35258-20-9 Diethyl-(2-{4-[(Z)-1-(4-methoxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-ethyl)-amine 
• 748-97-0 1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol 
• 749-16-6 3-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]-N,N-dimethylpropan-1-amine 
• 74631-77-9 1-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-butan-1-one 
• 68047-07-4 1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-2-phenyl-1-butanone 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation.

Studies in Potential Antifertility Agents: Part XXIV - Synthesis of 2,3-Disubstituted 4'-(&β-dialkylaminoethoxy)propiophenones

A number of 2,3-disubstituted 4'-(β-dialkylaminoethoxy)propiophenones (32-41) have been synthesized as the structural analogs of a potent antifertility agent erythro-2,3-diphenyl-4'-(β-pyrrolidinoethoxy)valerophenone (1).Compounds 34, 35, 38 and 40 show cent per cent activity at dose levels of 2.5, 10, 10, 10 and 1 mg/kg, respectively.The structure activity relationship has also been discussed.