69739-62-4

Basic information

• Product Name: 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE
• Synonyms: 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE
• CAS NO: 69739-62-4
• Molecular Formula: C₁₀H₉Cl
• Molecular Weight: 164.63146
• Mol File: 69739-62-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE(69739-62-4)
• EPA Substance Registry System: 6-CHLORO-1,2-DIHYDRO-NAPHTHALENE(69739-62-4)

Safety Data

• Hazardous Substances Data: 69739-62-4(Hazardous Substances Data)

Usage

General Description

6-CHLORO-1,2-DIHYDRO-NAPHTHALENE, also known as 6-chloro-1,2-dihydronaphthalene, is a chemical compound with the molecular formula C10H9Cl. It is a chlorinated derivative of 1,2-dihydronaphthalene and is used in the synthesis of various organic compounds. This chemical is a colorless to pale yellow liquid with a characteristic odor and is insoluble in water but soluble in organic solvents. It is primarily used in the production of pharmaceuticals, agrochemicals, and dyes. Additionally, it is also used as a research chemical in laboratory settings for various organic synthesis reactions. The compound is known to have potential health hazards and should be handled with care in a controlled environment.

Upstream product

• 108-90-7 chlorobenzene 
• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 69739-61-3 (±)-7-chloro-1,2,3,4-tetrahydronaphthalen-1-ol 
• 26673-32-5 7-chloro-3,4-dihydro-2H-naphthalen-1-one 

Downstream Products

• 91-58-7 2-chloronaphthalene 

Relevant articles and documents

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles

Bromodomain and extra-terminal domain (BET) inhibitors are widely used both as chemical tools to study the biological role of their targets in living organisms and as candidates for drug development against several cancer variants and human disorders. However, non-BET bromodomains such as those in p300 and CBP are less studied. XDM-CBP is a highly potent and selective inhibitor for the bromodomains of CBP and p300 derived from a pan-selective BET BRD-binding fragment. Along with X-ray crystal-structure analysis and thermodynamic profiling, XDM-CBP was used in screenings of several cancer cell lines in vitro to study its inhibitory potential on cancer cell proliferation. XDM-CBP is demonstrated to be a potent and selective CBP/p300 inhibitor that acts on specific cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia.

Intramolecular Aromatic Cyclizations of Alkenyliodonium Tetrafluoroborates

1,2-Dihydronaphthalene and 2H-chromene derivatives have been synthesized by thermal intramolecular cyclizations of alkenyliodonium tetrafluoroborates under mild reaction conditions.