69853-44-7

Basic information

• Product Name: bilirubin
• Synonyms: bilirubin
• CAS NO: 69853-44-7
• Molecular Weight: 584.672
• Mol File: 69853-44-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: bilirubin(CAS DataBase Reference)
• NIST Chemistry Reference: bilirubin(69853-44-7)
• EPA Substance Registry System: bilirubin(69853-44-7)

Safety Data

• Hazardous Substances Data: 69853-44-7(Hazardous Substances Data)

Upstream product

• 902268-70-6 biliverdin IXα 
• 69853-44-7 bilirubin 
• 635-65-4 bilirubin 

Downstream Products

• 120185-86-6 C₄₃H₅₂N₄O₁₀ 
• 635-65-4 bilirubin IXα 
• 81859-55-4 Lumirubin 
• 1451878-43-5 (Z)-2-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide 
• 329314-75-2 2-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)ethanamide 
• 21494-57-5 2-Methyl-3-vinylmaleimide 
• 902268-70-6 biliverdin IXα 
• 16883-97-9 phycocyanobilin 
• 114-25-0 biliverdin-IX_α 

Relevant articles and documents

A method for preparing high-content bilirubin IX[alpha] from bilirubin IX[alpha] diester

A method for preparing high-content bilirubin IX[alpha] from bilirubin IX[alpha] diester is disclosed, belonging to the field of bilirubin IX[alpha] preparation. The method includes following steps (aroute including firstly hydrolysis and then reduction): a step of adding dropwise a methanol solution of sodium hydroxide into an alcohol solution of bilirubin IX[alpha] diester, adding water, then performing hydrolysis, adjusting pH to 4-5 with a weak acid, performing rotary evaporation to remove a solvent, washing a product with water to remove inorganic salt, and performing vacuum drying to obtain bilirubin IX[alpha]; and a step of adding a free radical scavenger (stabilizer) into an alcohol solution of the bilirubin IX[alpha], adding a reductant that is borohydride, adding an acetone immediately after reduction is finished to decompose the excessive reductant, then adjusting pH to 4-5 with weak acid, performing rotary evaporation to remove a solvent, performing water washing, and performing purification with methanol and chloroform to obtain bilirubin IX[alpha] the purity of which is more than 97%. The method has characteristics of no need of chromatographic separation, mild reaction conditions, low cost, and convenient operation, and is suitable for industrial large-scale production.

Effects of Solvents and Media on the Efficiency and Course of Photoisomerization of Bilirubins

The quantum yields of photoisomerization of bilirubin to various isomers were determined in various solvents.A specific photoisomerization took place only in buffered solutions containing human serum albumin.We discuss the effects of solvents and media surrounding bilirubin on its photoisomerization.

The Structure of "Photobilirubin"

Anaerobic irradiation of bilirubin in the region of the main absorption band produces the diastereomers of (Z,E)- and (E,Z)-configurations with high quantum yield.The structure of these "photobilirubins" is proven by a chemical correlation with the corresponding diastereomers of biliverdindimethylester characterised before.Their 1H-NMR spectroscopic features have been recorded and are discussed. - Keywords: (Z,Z)-, (Z,E)- and (E,Z)-Bilirubin; Photobilirubin; Neonatal jaundice; Phototherapy