699-92-3

Basic information

• Product Name: 3''-Fluoro-2''-Hydroxyacetophenone
• Synonyms: 3''-Fluoro-2''-Hydroxyacetophenone;1-(3-Fluoro-2-hydroxyphenyl)-ethanone;1-(3-fluoro-2-hydroxyphenyl)ethan-1-one;1-(3-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-6-fluorophenol;3'-Fluoro-2'-hydroxyacetophenone 98%;Ethanone, 1-(3-fluoro-2-hydroxyphenyl)-;3'-Fluoro-2'-hydroxyacetophenone98%
• CAS NO: 699-92-3
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.139
• Mol File: 699-92-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 72-73 °C
• Boiling Point: 209.004 °C at 760 mmHg
• Flash Point: 80.203 °C
• Appearance: /
• Density: 1.247 g/cm³
• Vapor Pressure: 0.144mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.90±0.10(Predicted)
• CAS DataBase Reference: 3''-Fluoro-2''-Hydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3''-Fluoro-2''-Hydroxyacetophenone(699-92-3)
• EPA Substance Registry System: 3''-Fluoro-2''-Hydroxyacetophenone(699-92-3)

Safety Data

• Hazardous Substances Data: 699-92-3(Hazardous Substances Data)

Usage

Preparation

Obtained by Fries rearrangement of 2-fluorophenyl acetate with aluminium chloride without solvent at 115° 150° or at 180–190° (16%).

InChI:InChI=1/C8H7FO2/c1-5(10)6-3-2-4-7(9)8(6)11/h2-4,11H,1H3

Upstream product

• 29650-44-0 2-fluorophenyl acetate 
• 367-12-4 2-fluorophenol 
• 75-36-5 acetyl chloride 

Downstream Products

• 454689-23-7 6-fluoro-3-iodo-4H-1-benzopyran-4-one 
• 1384665-27-3 4-fluoro-2-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]pyrimido[1,2-a]benzimidazol-4-yl}phenol 
• 1384665-13-7 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]pyrazolo[1,5-a]pyrimidin-7-yl}phenol 
• 1384665-18-2 4-fluoro-2-{2-methyl-6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]pyrazolo[1,5-a]pyrimidin-7-yl}phenol 
• 1601269-10-6 2-ethoxy-3-fluoroacetophenone 
• 363-52-0 3-fluorocatechol 
• 226555-35-7 2,3-diethoxyfluorobenzene 
• 909302-85-8 2-ethoxy-3-fluorophenol 
• 1190962-28-7 tert-butyl 4-(4-((7-fluoro-2',3',5',6'-tetrahydrospiro[chromeno[3,4-d]pyrimidine-5,4'-pyrane]-3-yl)amino)phenyl)-piperazine-1-carboxylate 
• 75487-85-3 8-fluoro-4H-chromen-4-one 
• 1441772-46-8 8-fluoro-3-hydroxy-2-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one 

Relevant articles and documents

Discovery of novel 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole analogs as promising very long chain fatty acids inhibitors

Very long chain fatty acids (VLCFAs) are one of the most principal and promising targets for herbicides discovery. In order to explore and find novel VLCFAs inhibitors with higher herbicidal activity and improved crop safety, a variety of new 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole derivatives were reasonably designed and synthesized. The results of greenhouse experiments indicated that several compounds exhibited good herbicidal activity against Digitaria sanguinalis, Echinochloa crus-galli, and Setaria faberii at rates of 150 g ai/ha. Compounds g4 and h1 displayed promising herbicidal activity against D sanguinalis and E crus-galli at rates of 75 g ai/ha, which is better than commercial pyroxasulfone and S-metolachlor. Moreover, compound h1 displayed higher activity against E crus-galli, D sanguinalis, and S faberii than pyroxasulfone and S-metolachlor even at a rate of 37.5 and 18.75 g ai/ha. Furthermore, both of the compounds g4 and h1 were much safer to these tested crops, especially to rice, wheat and rape, at the rate of 150 g ai/ha than pyroxasulfone. Therefore, h1 may act as a new lead structure for novel herbicides discovery.

Isoxazoline derivative and application thereof in agriculture

The invention provides an isoxazoline derivative and an application thereof in agriculture. Specifically, the invention provides a compound shown in a formula (I) or a stereoisomer, nitrogen oxide orsalt of the compound shown in the formula (I), a preparation method, a composition containing the compound and an application of the composition in agriculture, in particular an application of the compound as a herbicide active ingredient for preventing and controlling unwanted plants, wherein R1, R2, R3, R4, n, R5, R6 and Hy have the meanings as described in the present invention.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.