69967-79-9Relevant articles and documents
Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent
Catanzaro, Elena,Seghetti, Francesca,Calcabrini, Cinzia,Rampa, Angela,Gobbi, Silvia,Sestili, Piero,Turrini, Eleonora,Maffei, Francesca,Hrelia, Patrizia,Bisi, Alessandra,Belluti, Federica,Fimognari, Carmela
, p. 538 - 549 (2019/02/24)
Breast cancer is the most diagnosed type of cancer among women for which an exhaustive cure has not been discovered yet. Nowadays, tamoxifen still represents the gold standard for breast cancer therapy; it acts on both estrogen receptor-positive and estrogen receptor-negative breast cancers. Unfortunately, its toxicity and the related chemoresistance undermine its antitumor potential. In this paper, new tamoxifen-based derivatives with a rigid structural motif in their structure were designed, synthesized, and evaluated to assess their antitumor behavior. All the tested compounds affected estrogen receptor-positive tumor (MCF-7) cell growth, even with different extents, among which, the most active ones proved also to induce mitochondria-mediated apoptosis through activation of PARP cleavage, decrease in Bax/Bcl-2 ratio and increase in Bim gene expression levels. Here we found that the compound 1, carrying a rigid xanthene core, turned out to be the most promising of the set showing an activity profile comparable to that of tamoxifen. Furthermore, a more favorable genotoxic profile than tamoxifen made compound 1 a promising candidate for further studies.
Synthesis, spectroscopic characterization, and molecular structure of triphenyl butene derivatives containing a cyclopentadienyl iron unit
Han, Junru,Li, Guanglei,Wang, Tao
, p. 374 - 379 (2013/01/13)
Three hydroxyl substituted triphenyl butene compounds (PHB) and their derivatives containing a cyclopentadienyl iron (PHB-Fc) unit were efficiently synthesized. The synthesis involved the McMurry cross-coupling reaction of appropriate ketones and the nucleophilic aromatic substitution (SNAr) reaction of (η6-chlorobenzene) (η5- cyclopentadienyl) iron hexafluorophosphate (Fc-Cl). The target compounds were characterized by IR, 1H NMR, 13C NMR, and MS. Their photophysical processes were investigated by UV-Vis absorption and fluorescence emission spectra in acetonitrile. The geometric structure was optimized based on the density functional theory at the B3LYP level. Theoretical results reveal that electron transfer occurred from the HOMO to the LUMO in PHB-Fc. The change in electron distribution subsequently led to the improved second-order optical susceptibility of PHB-Fc.
REDUCTIVE CONDENSATION OF 4-BENZYLOXYBENZOPHENONE AND PROPIOPHENONE, AND THE ESTROGENIC ACTIVITY OF 1-BENZYLOXY-4-(1,2-DIPHENYLBUT-1-ENYL)BENZENE
Zolotareva, V. A.,Klimova, L. I.,Malanina, G. G.,Sokolova, A. S.,Grinenko, G. S.
, p. 241 - 243 (2007/10/02)
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