701-44-0 Usage
Description
1-methyl-6-oxo-pyridine-3-carboxamide, also known as Nudifloramide, is a pyridone derivative that is a metabolite of niacin (or nicotinic acid) via nicotinamide. It is characterized by the presence of a carboxamide group at the C-3 position and a methyl group at the N-1 position. This light brown solid can be measured in serum and urine as part of metabolomic studies of niacin or nicotinamide intake and usage. Elevated levels of nudifloramide in patients receiving supplemental nicotinamide may be associated with toxic effects.
Uses
Used in Metabolomic Studies:
1-methyl-6-oxo-pyridine-3-carboxamide is used as a biomarker for assessing niacin or nicotinamide intake and usage in metabolomic studies. The expression is: 1-methyl-6-oxo-pyridine-3-carboxamide is used as a biomarker for [niacin or nicotinamide intake and usage assessment] because it is a metabolite of niacin and can be measured in serum and urine.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-methyl-6-oxo-pyridine-3-carboxamide is used as a starting material or intermediate for the synthesis of various pharmaceutical compounds. The expression is: 1-methyl-6-oxo-pyridine-3-carboxamide is used as a starting material or intermediate for [pharmaceutical compound synthesis] due to its unique chemical structure and reactivity.
Used in Toxicity Assessment:
1-methyl-6-oxo-pyridine-3-carboxamide is used as an indicator of potential toxic effects in patients receiving supplemental nicotinamide. The expression is: 1-methyl-6-oxo-pyridine-3-carboxamide is used as an indicator for [potential toxic effects assessment] in patients receiving supplemental nicotinamide because elevated levels of this metabolite may be associated with toxicity.
Used in Chemical Research:
In the field of chemical research, 1-methyl-6-oxo-pyridine-3-carboxamide serves as a model compound for studying the properties and reactivity of pyridone derivatives. The expression is: 1-methyl-6-oxo-pyridine-3-carboxamide is used as a model compound for [studying pyridone derivative properties and reactivity] due to its distinct chemical structure and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 701-44-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 701-44:
(5*7)+(4*0)+(3*1)+(2*4)+(1*4)=50
50 % 10 = 0
So 701-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)
701-44-0Relevant articles and documents
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Ruf, Sven,Hallur, Mahanandeesha Siddappa,Anchan, Nisha K.,Swamy, Indu N.,Murugesan, Karthikai Raj,Sarkar, Sayantani,Narasimhulu, Lokesh Kananti,Putta, V.P. Rama Kishore,Shaik, Shama,Chandrasekar, Devaraj Venkatapura,Mane, Vishal Subhash,Kadnur, Sanjay Venkatachalapathi,Suresh, Juluri,Bhamidipati, Ravi Kanth,Singh, Manvi,Burri, Raghunadha Reddy,Kristam, Rajendra,Schreuder, Herman,Czech, Joerg,Rudolph, Christine,Marker, Alexander,Langer, Thomas,Mullangi, Ramesh,Yura, Takeshi,Gosu, Ramachandraiah,Kannt, Aimo,Dhakshinamoorthy, Saravanakumar,Rajagopal, Sridharan
supporting information, p. 922 - 925 (2018/02/14)
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ～80% at 2 h when dosed in mice orally at 50 mg/kg.
HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS
-
Page/Page column 73, (2015/11/09)
The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical composi
IMINATION OF PYRIDINIUM AND QUINOLINIUM SALTS
Plas, H. C. van der,Buurman, D. J.
, p. 3763 - 3764 (2007/10/02)
A new method for imination of N-alkyl pyridinium- and quinolinium salts is described.It involves a low temperature oxidation of a solution of appropriate substrates in liquid ammonia with potassium permanganate.
