70206-22-3

Basic information

• Product Name: benzenepropanoate, beta-(aminomethyl)-4-chloro-, chloride (1:1)
• CAS NO: 70206-22-3
• Molecular Formula: C₁₀H₁₁Cl₂NO₂
• Molecular Weight: 248.1069
• Mol File: 70206-22-3.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 364.3°C at 760 mmHg
• Flash Point: 174.1°C
• Vapor Pressure: 6.01E-06mmHg at 25°C
• CAS DataBase Reference: benzenepropanoate, beta-(aminomethyl)-4-chloro-, chloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: benzenepropanoate, beta-(aminomethyl)-4-chloro-, chloride (1:1)(70206-22-3)
• EPA Substance Registry System: benzenepropanoate, beta-(aminomethyl)-4-chloro-, chloride (1:1)(70206-22-3)

Safety Data

• Hazardous Substances Data: 70206-22-3(Hazardous Substances Data)

Upstream product

• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 750649-51-5 (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid 
• 104-88-1 4-chlorobenzaldehyde 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 22518-27-0 4-(4-chlorophenyl)pyrrolidin-2-one 
• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 137310-16-8 (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester 
• 69308-37-8 (R)-baclofen 
• 834917-63-4 ethyl (4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate 
• 290366-79-9 (R)-(-)-3-(4-chloro-phenyl)-4-nitro-butyric acid 

Relevant articles and documents

Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications

A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkene

Assembling of medium/long chain-based β-arylated unnatural amino acid derivatives via the Pd(II)-catalyzed sp3 β-C-H arylation and a short route for rolipram-type derivatives

In this paper, we report the assembling of libraries of β-arylated short/medium/long chain-based non-α-amino acid (aminoalkanoic acid) derivatives via the Pd(II)-catalyzed, bidentate directing group 8-aminoquinoline-aided sp3 β-C-H activation/arylation method. Short/medium chain-based unnatural amino acid derivatives containing an aryl group at the β-position are promising small molecules with therapeutic properties. Thus, it is necessary to enrich the libraries of short/medium/long chain-based unnatural amino acid derivatives containing an aryl group at the β-position. Considering the importance of β-arylated short/medium/long chain-based non-α-amino acid derivatives, an inclusive attention was paid to explore the Pd(II)-catalyzed sp3 β-C-H arylation of short/medium/long chain-based non-α-amino acids. Representative synthetic transformations including a short route for the assembling of rolipram and related compounds and 3-arylated GABA derivatives such as, baclofen, phenibut and tolibut were shown using selected β-C-H arylated non-α-amino acid derivatives.

A novel method for the synthesis of racemic pregabalin, baclofen and 3-phenibut involving lossen rearrangement

Pregabalin,baclofen,and3-phenibutareγ-aminobutyricacid receptorsusedasanticonvulsant agents. The racemic forms of these anticonvulsants have been prepared by Lossen rearrangement. This procedure also provides an easy method to prepare carbamates useful intermediates to prepare anticonvulsants. This process is economical and easy to scale-up and yields are good.