70237-25-1

Basic information

• Product Name: 3-CHLORO-2-IODO-PHENYLAMINE
• Synonyms: 3-CHLORO-2-IODO-PHENYLAMINE;3-chloro-2-iodoaniline;Benzenamine, 3-chloro-2-iodo-;2-Iodo-3-chloroaniline;3-Chloro-2-iodobenzenaMine
• CAS NO: 70237-25-1
• Molecular Formula: C6H5ClIN
• Molecular Weight: 253.47
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70237-25-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304℃
• Flash Point: 137℃
• Appearance: /
• Density: 2.015
• Vapor Pressure: 0.000925mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.48±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-2-IODO-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-IODO-PHENYLAMINE(70237-25-1)
• EPA Substance Registry System: 3-CHLORO-2-IODO-PHENYLAMINE(70237-25-1)

Safety Data

• Hazardous Substances Data: 70237-25-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 70237-25-1 differently. You can refer to the following data:
1. 3-Chloro-2-iodoaniline is used in the preparation of indolyl benzoic acid derivatives as NURR-1 activators for the treatment of Parkinson's disease.
2. 3-Chloro-2-iodoaniline is used in the preparation of indolyl benzoic acid derivatives as NURR-1 activators for the treatment of Parkinson''s disease.

InChI:InChI=1/C6H5ClIN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2

Upstream product

• 108-42-9 3-chloro-aniline 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 858854-82-7 3-chloro-2-iodo-phenol 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 32337-97-6 1-chloro-2-iodo-3-nitrobenzene 
• 603-86-1 2-chloro-6-nitrophenol 
• 769-11-9 2-chloro-6-nitroaniline 
• 121-73-3 3-Nitrochlorobenzene 

Downstream Products

• 72995-15-4 5-chloro-3,4-dihydro-2(1H)-quinolinone 
• 882023-24-7 2-oxo-1,2,3,4-tetrahydroquinoline-5-carbonitrile 
• 1849-73-6 2-mercapto-7-chlorobenzothiazole 

Relevant articles and documents

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Compounds and Uses Thereof

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of anxiety disorders, cognitive disorders, and/or mood disorders.