72995-15-4 Usage
Description
5-chloro-3,4-dihydroquinolin-2(1H)-one is a chemical compound with the molecular formula C9H8ClNO. It is an organic compound that belongs to the quinoline family, which is commonly found in various pharmaceuticals and agrochemicals. 5-chloro-3,4-dihydroquinolin-2(1H)-one is known for its potential medicinal properties and is often used as a building block in the synthesis of different pharmaceutical drugs. It is also used as an intermediate in the production of various organic compounds. The presence of a chlorine atom and a carbonyl group in its structure makes 5-chloro-3,4-dihydroquinolin-2(1H)-one an important compound in the field of organic chemistry with a wide range of applications.
Uses
Used in Pharmaceutical Industry:
5-chloro-3,4-dihydroquinolin-2(1H)-one is used as a building block for the synthesis of various pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Agrochemical Industry:
5-chloro-3,4-dihydroquinolin-2(1H)-one is used as an intermediate in the production of various agrochemicals. Its potential medicinal properties and versatility in chemical reactions contribute to its use in this industry.
Used in Organic Chemistry Research:
5-chloro-3,4-dihydroquinolin-2(1H)-one is used as a research compound in the field of organic chemistry. Its unique structure and properties make it an important compound for studying various chemical reactions and processes.
Used in Organic Compound Production:
5-chloro-3,4-dihydroquinolin-2(1H)-one is used as an intermediate in the production of various organic compounds. Its versatility in chemical reactions and potential medicinal properties make it a valuable component in the synthesis of different organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 72995-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,9,9 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 72995-15:
(7*7)+(6*2)+(5*9)+(4*9)+(3*5)+(2*1)+(1*5)=164
164 % 10 = 4
So 72995-15-4 is a valid CAS Registry Number.
72995-15-4Relevant articles and documents
2-AMINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
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Paragraph 0084-0085, (2021/03/04)
The disclosure provides an aminopyrimidine derivative for preventing and treating diseases related to IDH mutation, a preparation method and use thereof. Specifically, the disclosure provides a compound of Formula I, a stereoisomer, racemate thereof, or pharmaceutically acceptable salt thereof. The compound of the general Formula I has isocitrate dehydrogenase 1 (IDH1) inhibitory activity and can treat cancer induced by IDH1 mutation.
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration
Cao, Hengyi,Zhu, Guangya,Sun, Lin,Chen, Ge,Ma, Xinxin,Luo, Xiao,Zhu, Jidong
, (2019/09/30)
Isocitrate dehydrogenase 1 (IDH1), which catalyzes the conversion of isocitrate to α-ketoglutarate, is one of key enzymes in the tricarboxylic acid cycle (TCA). Hotspot mutation at Arg132 in IDH1 that alters the function of IDH1 by further converting the α-ketoglutarate(α-KG) to 2-hydroxyglutarate (2-HG) have been identified in a variety of cancers. Because the IDH1 mutations occur in a significant portion of gliomas and glioblastomas, it is important that IDH1 inhibitors have to be brain penetrant to treat IDH1-mutant brain tumors. Here we report the efforts to design and synthesize a novel serial of mutant IDH1 inhibitors with improved activity and the blood-brain barrier (BBB) penetration. We show that compound 5 exhibits good brain exposure and potent 2-HG inhibition in a HT1080-derived mouse xenograft model, which makes it a potential preclinical candidate to treat IDH1-mutant brain tumors.
NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
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Page/Page column 41, (2016/05/19)
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R10, R11, R12, R13, R14, R15, R16, R17 and m are as described herein, compositions including the compounds and methods of using the compounds.
