70445-33-9 Usage
Description
3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, also known as Ethylhexylglycerin, is a glyceryl ether derived from natural glycerin. It is a colorless to pale viscous liquid with a slightly characteristic odor. Ethylhexylglycerin is a weak preservative and skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth. It is rather stable, resistant to hydrolysis and elevated temperatures, and compatible with cosmetic ingredients. Ethylhexylglycerin is globally approved and listed on the ELINCS file, with international approvals in Europe, the USA, Australia, Canada, and Japan.
Uses
Used in Cosmetic Industry:
3-[2-(Ethylhexyl)oxyl]-1,2-propandiol is used as a natural preservative for cosmetic products, serving as an alternative to parabens. It is used in various cosmetic products such as anti-aging creams, sunscreens, eye shadows, eye creams, lip gloss, deodorants, facial moisturizers, and cleansers.
Used in Deodorant Application:
Ethylhexylglycerin is the novel raw material for deodorants and is widely used as a cosmetic emollient. It reliably inhibits odor-causing bacteria, yeast, and fungi on the skin.
Used as an Emollient Solvent and Fixative:
3-[2-(Ethylhexyl)oxyl]-1,2-propandiol serves as an emollient solvent and a fixative with antimicrobial properties. It is reported to enhance the uptake of preservatives in microorganisms and is often used as an alternative to parabens.
Used in Leave-on and Rinsed-off Products:
Ethylhexylglycerin is used at a concentration up to 2% in leave-on products and 8% in rinse-off products, making it suitable for a wide range of cosmetic applications.
Safety
With an EWG score of 1 and a rating of GOOD from Paula’s Choice, ethylhexylgylcerin is deemed to be very safe and a non-irritant.Ethylhexylglycerin is a topical skin care ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. It can also be a surfactant and preservative-enhancer and can be found as a substituent for parabens. Ethylhexylglycerin is commonly found in baby products or cosmetics marketed as “hypoallergenic” or “formaldehyde free”.Ethylhexylglycerin has been reported to cause dermatitis and skin irritation.www.cir-safety.orgWhat Is Ethylhexylglcerin & Is It Safe?
Toxicity evaluation
The oral toxicity of ethylhexylglycerin (Sensiva? SC 50, in polyethylene glycol 400) at doses of 100, 500, and 1,500 mg/kg was evaluated in a 28-day study using groups of 10 rats of an unspecified strain. The test substance was administered at a dose volume of 5 ml/kg.There were no treatment-related mortalities. Body weight development was retarded in mid- and high-dose groups, and this finding was accompanied by a non-statistically significant reduction in food intake when compared to the control (polyethylene glycol 400) group. Both eye and ear functions remained unchanged during the study, and increased salivation (dose not stated) was the only clinical symptom observed. Hematological parameters were unaffected by treatment; however, serum analyses indicated changes in aminotransferase (above normal) in high-dose rats. Urinalysis and necropsy findings were unremarkable.
Reference
W. Beilfuss, M. Leschke, K. Weber, A New Concept to Boost the Preservative Efficacy of Phenoxyethanol, S?FW-Journal, 2005, vol. 131
Contact allergens
This glycerol monoalkylether is used as a skin conditioning
agent, with bactericidal properties against
Gram-positive bacteria.
Synthesis
Synthesis of ethylhexylglycerin?is via the catalytic splitting of ethylhexylglycidyl ether followed by the addition of water. The product can then be purified by vacuum distillation.
Check Digit Verification of cas no
The CAS Registry Mumber 70445-33-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,4 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70445-33:
(7*7)+(6*0)+(5*4)+(4*4)+(3*5)+(2*3)+(1*3)=109
109 % 10 = 9
So 70445-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H24O3/c1-3-5-6-10(4-2)8-14-9-11(13)7-12/h10-13H,3-9H2,1-2H3
70445-33-9Relevant articles and documents
Method for continuously synthesizing ethylhexylglycerin by micro-channel reactor
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Paragraph 0026-0033, (2021/04/17)
The invention discloses a method for continuously synthesizing ethylhexylglycerin by using a micro-channel reactor. The method comprises the following steps: by using isooctyl alcohol, 3-chloro-1, 2-propylene glycol and inorganic base as raw materials, carrying out ethylhexylglycerin continuous synthesis by using the micro-channel reactor, separating the organic phase from a product, distilling and the like to obtain the high-purity ethylhexylglycerin product. According to the process method disclosed by the invention, the characteristics that the micro-channel reactor strengthens heat transfer and mass transfer and can realize accurate control are fully utilized; the defects of more byproducts, difficulty in control, poorer reaction selectivity, low product yield, complicated process, higher cost and the like caused by non-uniform reaction heating when the ethylhexylglycerin is synthesized by the conventional reactor equipment are overcome, continuous production and automatic control of the process can be realized, production is efficient and safe in production, mild reaction conditions, short reaction time, high product purity and yield are also realized, and the method is green and economic, and is beneficial to popularization and application of ethylhexylglycerin in cosmetics and daily chemical industries.
A process for preparing ethyl hexyl glycerin method
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Paragraph 0031; 0032; 0033; 0035; 0038, (2018/07/15)
This invention discloses a process for preparing ethyl hexyl glycerin method, comprises the following steps: (1) in order to boron trifluoride ether solution is used as the catalyst, under stirring condition, make the isooctanol and glycidyl ester type of stirring at room temperature the reaction, to produce intermediate; (2) in the step (1) and capable of adding acid as catalyst, and then adding water or alcohol, under the conditions of normal pressure or reduced in the reaction, so that the steps (1) intermediate obtained by hydrolysis or alcoholysis; (3) the step (2) of the product after washing liquid, ethyl hexyl glycerin through distillation. The invention of the method of preparing ethyl hexyl glycerin operation process is simple, mild reaction conditions, low energy consumption, is suitable for the large-scale industrial production, can be colorless ethyl hexyl glycerin, product yield is greater than 82%, the purity of 99% or more.
The Preparation method of 2-ethylhexylglycerolether from 2-ethylhexylglycidylether by gas phase hydrolysis
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Paragraph 0055-0058, (2017/10/13)
The present invention relates to a method for manufacturing 2-ethyl hexyl glycerol ether, which performs hydrolysis of 2-ethyl hexyl glycidyl ether by reacting the 2-ethyl hexyl glycidyl ether with water, while controlling the reaction temperature at the temperature of 250-350anddeg;C to process the reaction in a gas phase. In the present invention, by applying a method of vapor phase hydrolysis of 2-ethyl hexyl glycidyl ether in the manufacture of 2-ethyl hexyl glycerol ether, it is possible to ensure simplification and efficiency of manufacturing processes, and to achieve a high yield of 2-ethyl hexyl glycerol ether which is a target material by inhibiting the generation of 2-ethyl hexyl glycerol ether dimer byproducts in a reaction step.(AA) Vaporizer(BB) Controlled volume pump(CC) 2-ethyl hexyl glycidyl ether(DD) Water(EE) Vapor phase hydrolysis reactor(FF) Condensate plate(GG) Exhaust treatment(HH) Vacuum pump(II) Low temperature cooing device(JJ) Product collecting device(KK) 2-ethyl hexyl glycidyl ether purification processCOPYRIGHT KIPO 2017
