6387-89-9Relevant articles and documents
3-(Acyloxy)propanolamines: agents with β-adrenergic blocking activity
Leuschner, J.,Schaefer, H.,Leuschner, F.
, p. 241 - 244 (1994)
A series of totally aliphatic 3-(acyloxy)propanolamine derivatives were prepared and their pA2-values were determined employing the guinea-pig atrium.Compounds, with an acetyl or methyl succinoyl half ester moiety showed a pronounced β1-adrenergic blocking activity.Keywords: 3-(acyloxy)propanolamines / β1-adrenergic blocking activity
Poly(Alkyl Glycidate Carbonate)s as Degradable Pressure-Sensitive Adhesives
Beharaj, Anjeza,Ekladious, Iriny,Grinstaff, Mark W.
supporting information, p. 1407 - 1411 (2019/01/14)
Insertion of CO2 into the polyacrylate backbone, forming poly(carbonate) analogues, provides an environmentally friendly and biocompatible alternative. The synthesis of five poly(carbonate) analogues of poly(methyl acrylate), poly(ethyl acrylate), and poly(butyl acrylate) is described. The polymers are prepared using the salen cobalt(III) complex catalyzed copolymerization of CO2 and a derivatized oxirane. All the carbonate analogues possess higher glass-transition temperatures (Tg=32 to ?5 °C) than alkyl acrylates (Tg=10 to ?50 °C), however, the carbonate analogues (Td≈230 °C) undergo thermal decomposition at lower temperatures than their acrylate counterparts (Td≈380 °C). The poly(alkyl carbonates) exhibit compositional-dependent adhesivity. The poly(carbonate) analogues degrade into glycerol, alcohol, and CO2 in a time- and pH-dependent manner with the rate of degradation accelerated at higher pH conditions, in contrast to poly(acrylate)s.
Synthesis and enzymatic resolution of racemic 2,3-epoxy propyl esters obtained from glycerol
Araujo, Yara Jaqueline Kerber,Avvari, Naga Prasad,Paiva, Derisvaldo Rosa,De Lima, Dênis Pires,Beatriz, Adilson
supporting information, p. 1696 - 1698 (2015/03/14)
A method is described for the synthesis of (±)-2,3-epoxy propyl esters from glycerol, involving reaction of epichlorohydrin with sodium or potassium salts of carboxylic acids in the presence of TBAB as catalyst, with moderate to excellent yields. Kinetic resolution of glycidyl butyrate by lipase of Thermomyces lanuginosa has been achieved with remarkable enantiomeric excess (ee >99%) using 1,4-dioxane as a co-solvent in pure buffer solution (30 and 50 °C, pH = 7.0).