7050-24-0

Basic information

• Product Name: 18-hydroxy-11-dehydrotetrahydrocorticosterone
• Synonyms: 18-hydroxy-11-dehydrotetrahydrocorticosterone;3α,18,21-Trihydroxy-5β-pregnane-11,20-dione
• CAS NO: 7050-24-0
• Molecular Formula: C21H32O5
• Molecular Weight: 364.47578
• Mol File: 7050-24-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 555.3°C at 760 mmHg
• Flash Point: 303.7°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 1.21E-14mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 18-hydroxy-11-dehydrotetrahydrocorticosterone(CAS DataBase Reference)
• NIST Chemistry Reference: 18-hydroxy-11-dehydrotetrahydrocorticosterone(7050-24-0)
• EPA Substance Registry System: 18-hydroxy-11-dehydrotetrahydrocorticosterone(7050-24-0)

Safety Data

• Hazardous Substances Data: 7050-24-0(Hazardous Substances Data)

Usage

Description

18-hydroxy-11-dehydrotetrahydrocorticosterone, also known as (3α,5β)-3,18,21-Trihydroxypregnane-11,20-dione, is a derivative of Tetrahydrodehydrocorticosterone (T293165). It is a steroid hormone that plays a crucial role in the regulation of aldosteronogenesis.
Used in Pharmaceutical Industry:
18-hydroxy-11-dehydrotetrahydrocorticosterone is used as an aldosterone antagonist for the treatment of hypertension and heart failure. It inhibits aldosteronogenesis by intact cells at concentrations that inhibit angiotensin binding, leading to a reduction in blood pressure and improved heart function.
Used in Research Applications:
18-hydroxy-11-dehydrotetrahydrocorticosterone is used as a research tool for studying the mechanisms of aldosteronogenesis and the role of aldosterone in various physiological processes. It helps researchers understand the molecular pathways involved in the regulation of blood pressure and fluid balance in the body.

InChI:InChI=1/C21H32O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h12-16,19,22-24H,2-11H2,1H3/t12-,13-,14+,15+,16-,19-,20+,21-/m1/s1