7074-09-1

Basic information

• Product Name: 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one
• Synonyms: 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one
• CAS NO: 7074-09-1
• Molecular Weight: 248.322
• Mol File: 7074-09-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one(7074-09-1)
• EPA Substance Registry System: 4-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]butan-2-one(7074-09-1)

Safety Data

• Hazardous Substances Data: 7074-09-1(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 

Downstream Products

• 256946-31-3 5-hydroxy-7-phenyl-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-heptan-3-one 
• 1265304-10-6 (+/-)-5-hydroxy-1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)icosan-3-one 
• 1265304-31-1 (+/-)-4-(5-hydroxy-3-oxoicosyl)-4-methoxycyclohexa-2,5-dienone 
• 1265304-30-0 (+/-)-5-hydroxy-1-(4-hydroxyphenyl)icosan-3-one 
• 105955-04-2 (+/-)-5-hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone 
• 41137-85-3 (+/-)-5-hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone 

Relevant articles and documents

Heterogeneous acidic catalysts for the tetrahydropyranylation of alcohols and phenols in green ethereal solvents

The application of heterogeneous catalysis and green solvents to the set up of widely employed reactions is a challenge in contemporary organic chemistry. We applied such an approach to the synthesis and further conversion of tetrahydropyranyl ethers, an important class of compounds widely employed in multistep syntheses. Several alcohols and phenols were almost quantitatively converted into the corresponding tetrahydropyranyl ethers in cyclopentyl methyl ether or 2-methyltetrahydrofuran employing NH4HSO4 supported on SiO2 as a recyclable acidic catalyst. Easy work up of the reaction mixtures and the versatility of the solvents allowed further conversion of the reaction products under one-pot reaction conditions.

Synthesis and digestibility inhibition of diarylheptanoids: Structure- activity relationship

(±)-5-Hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone (2a), (±)5- hydroxyl-1-(4'-hydroxyphenyl)-7-phenyl-3-heptanone (2b), (±)-5-hydroxy-7- (4'-hydroxyphenyl)-1-phenyl-3-heptanone (2c), and (±)-5-hydroxy-1,7- bis(phenyl)-3-heptanone (2d) have been synthesized to study the structure- activity relationship regarding digestibility inhibition in vitro in cow rumen fluid. The activities were compared with the activity of chiral (S)-2a and its glucoside platyphylloside (1), isolated from Betula pendula. Compound 2a was slightly less active, 2b and 2c were more active, and 2d was less active than (S)-2a and platyphylloside.