70904-56-2 Usage
General Description
Kyotorphin, a natural dipeptide compound consisting of two amino acids, L-tyrosine and L-arginine, was first discovered in the brain of mammals at Kyoto University, hence its name. It's a neuroactive dipeptide that plays a significant role in pain regulation in the central nervous system. It works by stimulating the release of Met-enkephalin and Leu-enkephalin, two opioids that help inhibit pain signals in the brain. Despite its analgesic properties, it doesn't pass through the blood-brain barrier, which poses a challenge in using it directly as a pain relief drug.
Check Digit Verification of cas no
The CAS Registry Mumber 70904-56-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,9,0 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 70904-56:
(7*7)+(6*0)+(5*9)+(4*0)+(3*4)+(2*5)+(1*6)=122
122 % 10 = 2
So 70904-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H23N5O4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19)/t11-,12-/m0/s1
70904-56-2Relevant articles and documents
SINGLE-STEP SYNTHESIS OF KYOTORPHIN IN FROZEN SOLUTIONS BY CHYMOTRYPSIN
Meos, Helle,Tougu, Vello,Haga, Mati,Aaviksaar, Aavo,Schuster, Matthias,Jakubke, Hans-Dieter
, p. 1559 - 1564 (2007/10/02)
A novel method of Kyotorphin (H-Tyr-Arg-OH) synthesis without protecting and deprotecting procedures is described - α-chymotrypsin-catalyzed aminolysis of H-Tyr-OEt by H-Arg-OH in frozen mixtures.In this one step process yields of the peptide product above 80percent have been obtained.
