70931-61-2 Usage
Description
(4-fluoro-2-iodophenyl)acetic acid is a chemical compound with the formula C8H6FIO2, which is a derivative of acetic acid featuring a 4-fluoro-2-iodophenyl group attached to the acetic acid molecule. (4-fluoro-2-iodophenyl)acetic acid is known for its unique reactivity and properties due to the presence of both fluorine and iodine in its molecular structure, making it a valuable tool in the development of new molecules and materials.
Uses
Used in Organic Synthesis:
(4-fluoro-2-iodophenyl)acetic acid is used as a building block in organic synthesis for the production of other chemicals and drugs. Its versatile reactivity allows it to participate in various types of chemical reactions, such as coupling reactions and metal-catalyzed transformations.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-fluoro-2-iodophenyl)acetic acid is used as a key intermediate in the development of new drugs. Its unique molecular structure with fluorine and iodine atoms provides specific properties that can be exploited to design and synthesize novel therapeutic agents.
Used in Chemical Reactions:
(4-fluoro-2-iodophenyl)acetic acid is utilized as a versatile reagent in chemical reactions, where its fluorine and iodine atoms can influence the reaction pathways and outcomes. This makes it a valuable component in the synthesis of complex organic molecules and materials with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 70931-61-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,9,3 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70931-61:
(7*7)+(6*0)+(5*9)+(4*3)+(3*1)+(2*6)+(1*1)=122
122 % 10 = 2
So 70931-61-2 is a valid CAS Registry Number.
70931-61-2Relevant articles and documents
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis
Chen, Lin-Hai,Fang, You-Chen,Nan, Fa-Jun,Xiao, Yu-Feng,Xie, Xin,Zhang, Qing
, p. 3991 - 4006 (2022/03/14)
GPR84 is a proinflammatory G protein-coupled receptor associated with several inflammatory and fibrotic diseases. GPR84 antagonists have been evaluated in clinical trials to treat ulcerative colitis, idiopathic pulmonary fibrosis, and nonalcoholic steatohepatitis. However, the variety of potent and selective GPR84 antagonists is still limited. Through high-throughput screening, a novel phosphodiester compound hit 1 was identified as a GPR84 antagonist. The subsequent structural optimization led to the identification of compound 33 with improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. In a DSS-induced mouse model of ulcerative colitis, compound 33 significantly alleviated colitis symptoms and reduced the disease activity index score at oral doses of 25 mg/kg qd, with an efficacy similar to that of positive control 5-aminosalicylic acid (200 mg/kg, qd, po), suggesting that compound 33 is a promising candidate for further drug development.
