7100-97-2

Basic information

• Product Name: Benzene, (1-fluoroethyl)-
• CAS NO: 7100-97-2
• Molecular Formula: C8H9F
• Molecular Weight: 124.158
• Mol File: 7100-97-2.mol
• Article Data: 50

Chemical Properties

• CAS DataBase Reference: Benzene, (1-fluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (1-fluoroethyl)-(7100-97-2)
• EPA Substance Registry System: Benzene, (1-fluoroethyl)-(7100-97-2)

Safety Data

• Hazardous Substances Data: 7100-97-2(Hazardous Substances Data)

Usage

General Description

Benzene, (1-fluoroethyl)- is a chemical compound with the formula C8H9F. It is a colorless liquid with a sweet odor and is commonly used in organic synthesis and as a solvent in the production of drugs and dyes. Benzene, (1-fluoroethyl)- is also used as a precursor in the production of fluorine-containing compounds and can be found in some consumer products. It is important to handle this chemical with caution, as it is considered hazardous and can have harmful effects on human health and the environment. Exposure to this compound can cause irritation to the skin, eyes, and respiratory system, and long-term exposure has been linked to an increased risk of cancer. Therefore, proper safety measures and protective equipment should be used when working with or handling benzene, (1-fluoroethyl)-.

Upstream product

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Downstream Products

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Relevant articles and documents

Insertion of Diazo Esters into C-F Bonds toward Diastereoselective One-Carbon Elongation of Benzylic Fluorides: Unprecedented BF3Catalysis with C-F Bond Cleavage and Re-formation

Selective transformation of C-F bonds remains a significant goal in organic chemistry, but C-F insertion of a one-carbon-atom unit has never been established. Herein we report the BF3-catalyzed formal insertion of diazo esters as one-carbon-atom sources into C-F bonds to accomplish one-carbon elongation of benzylic fluorides. A DFT calculation study revealed that the BF3 catalyst could contribute to both C-F bond cleavage and re-formation. This elongation provided α-fluoro-α,β-diaryl esters with a high level of diastereoselectivity. Various benzylic fluorides and diazo esters were applicable. The synthetic utility of this method was demonstrated by the synthesis of a fluoro analogue of a compound that is used as a transient receptor and potential canonical channel inhibitor.

Fast Hydrocarbon Oxidation by a High-Valent Nickel–Fluoride Complex

In the search for highly reactive oxidants we have identified high-valent metal–fluorides as a potential potent oxidant. The high-valent Ni–F complex [NiIII(F)(L)] (2, L=N,N′-(2,6-dimethylphenyl)-2,6-pyridinedicarboxamidate) was prepared from [NiII(F)(L)]? (1) by oxidation with selectfluor. Complexes 1 and 2 were characterized by using 1H/19F NMR, UV-vis, and EPR spectroscopies, mass spectrometry, and X-ray crystallography. Complex 2 was found to be a highly reactive oxidant in the oxidation of hydrocarbons. Kinetic data and products analysis demonstrate a hydrogen atom transfer mechanism of oxidation. The rate constant determined for the oxidation of 9,10-dihydroanthracene (k2=29 m?1 s?1) compared favorably with the most reactive high-valent metallo-oxidants. Complex 2 displayed reaction rates 2000–4500-fold enhanced with respect to [NiIII(Cl)(L)] and also displayed high kinetic isotope effect values. Oxidative hydrocarbon and phosphine fluorination was achieved. Our results provide an interesting direction in designing catalysts for hydrocarbon oxidation and fluorination.