71569-15-8

Basic information

• Product Name: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE
• Synonyms: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE;5,6,7,8-TETRAHYDRO-QUINOLIN-5-YLAMINE;5,6,7,8-Tetrahydroquinolin-5-amine;5,6,7,8-tetrahydroquinolin-5-amine dihydrochloride;5,6,7,8-tetrahydro-5-quinolinamine(SALTDATA: 2HCl);5,6,7,8-tetrahydro-5-QuinolinaMine
• CAS NO: 71569-15-8
• Molecular Formula: C9H12N2
• Molecular Weight: 148.2
• Product Categories: pharmacetical
• Mol File: 71569-15-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 259.1 °C at 760 mmHg
• Flash Point: 134.3 °C
• Appearance: /
• Density: 1.081 g/cm³
• Vapor Pressure: 0.0132mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.57±0.20(Predicted)
• CAS DataBase Reference: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE(71569-15-8)
• EPA Substance Registry System: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE(71569-15-8)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 71569-15-8(Hazardous Substances Data)

Usage

General Description

5-Amino-5,6,7,8-tetrahydroquinoline is a chemical compound with the molecular formula C9H12N2. This chemical is known for its vast application in the pharmaceutical industry. The presence of an amino group in its chemical structure allows it to participate in a wide range of reactions, making it a suitable candidate for the synthesis of numerous drugs. It is also classified as an aromatic heterocyclic organic compound, which refers to its stable ring structure with alternating double and single bonds. The chemical's structure offers the potential for bioactive properties, revealing its importance in medicinal chemistry. Moreover, compounds like 5-Amino-5,6,7,8-tetrahydroquinoline are often used as intermediates in the production of more complex pharmaceuticals.

InChI:InChI=1/C9H12N2/c10-8-4-1-5-9-7(8)3-2-6-11-9/h2-3,6,8H,1,4-5,10H2

Upstream product

• 53400-41-2 5,6,7,8-tetrahydroquinolin-5-one 
• 1114896-36-4 (Z/E)-7,8-dihydroquinolin-5(6H)-one O-methyl oxime 
• 185510-52-5 5-(N-acetylamino)-5,6,7,8-tetrahydroquinoline 
• 298182-09-9 N-(5,6,7,8-tetrahydroquinolin-7-yl)acetamide 

Downstream Products

• 911825-73-5 (S)-5,6,7,8-tetrahydroquinolin-5-ylamine 

Relevant articles and documents

CXCR2 ANTAGONIST

A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Chemokine receptor binding heterocyclic compounds

This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines. The present invention provides a compound of Formula I wherein, W is a nitrogen atom and Y is absent or, W is a carbon atom and Y═H; R1to R7may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C1-6alkyl; R8is a substituted heterocyclic group or a substituted aromatic group Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and n′ are independently, 0-2; X is a group of the formula: Wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom. Ring B is an optionally substituted 5 to 7-membered ring. Ring A and Ring B in the above formula can be connected to the group W from any position via the group V, wherein V is a chemical bond, a (CH2)n″group (where n″=0-2) or a C═O group. Z is, (1) a hydrogen atom, (2) an optionally substituted C1-6alkyl group, (3) a C0-6alkyl group substituted with an optionally substituted aromatic or heterocyclic group, (4) an optionally substituted C0-6alkylamino or C3-7cycloalkylamino group, (5) an optionally substituted carbonyl group or sulfonyl. These compounds further include any pharmaceutically acceptable acid addition salts and metal complexes thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof.