718610-71-0

Basic information

• Product Name: (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester
• Synonyms: (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester
• CAS NO: 718610-71-0
• Molecular Weight: 445.506
• Mol File: 718610-71-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester(718610-71-0)
• EPA Substance Registry System: (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester(718610-71-0)

Safety Data

• Hazardous Substances Data: 718610-71-0(Hazardous Substances Data)

Upstream product

• 718610-70-9 N-(benzyloxycarbonylpiperidin-4-yl)propenoic acid isopropyl ester 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 527693-82-9 3-[N-(benzyloxycarbonylpiperidin-4-yl)]propenoic acid 

Downstream Products

• 718610-24-3 (R) N-(3-[3,5-difluorophenyl]-3-[1-methanesulphonylpiperidin-4-yl]propyl)-4-[2-(4-methanesulphonylphenylsulphonyl)-ethyl]piperidine 
• 835876-97-6 tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-piperidin-4-yl]propyl}piperidin-4-yl)methyl]carbamate 
• 835876-98-7 1-(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)piperidin-4-yl]propyl}piperidin-4-yl)methanamine 
• 718610-73-2 (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate 
• 718610-74-3 (3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)piperidin-4-yl]propan-1-ol 
• 718610-25-4 (R) 3-(1-methanesulphonylpiperidin-4-yl)-3-[3,5-difluorophenyl]propionaldehyde 

Relevant articles and documents

PROCESS FOR PREPARING BETA- (FLUOROPHENYL) -PROPANOATE ESTER DERIVATIVES

A process for preparing a compound of formula (I) comprising reacting a compound of formula (II) with a fluorinated boron species of formula (III) in the presence of: an alcohol; a rhodium (I) pre-catalyst species; a suitable ligand that binds to the rhodium (I) pre-catalyst species to form a catalyst complex; a base; and, a suitable solvent; the process being carried out at a temperature in the range 40 to 110oC. The compounds of formula (I) are useful in the preparation of pharmaceutically active compounds.

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein R1, R2, R3, R4, A, X, m and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).