718610-73-2

Basic information

• Product Name: (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate
• Synonyms: (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate
• CAS NO: 718610-73-2
• Molecular Weight: 389.464
• Mol File: 718610-73-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate(718610-73-2)
• EPA Substance Registry System: (R)-iso-propyl 3-(3,5-difluorophenyl)-3-(1-(methylsulfonyl)piperidine-4-yl)propanoate(718610-73-2)

Safety Data

• Hazardous Substances Data: 718610-73-2(Hazardous Substances Data)

Upstream product

• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 718610-70-9 N-(benzyloxycarbonylpiperidin-4-yl)propenoic acid isopropyl ester 
• 718610-71-0 (R)-3-[N-(benzyloxycarbonyl)piperidin-4-yl]-3-(3,5-difluorophenyl)propanoic acid isopropyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 241134-34-9 (1-(methylsulfonyl)piperidin-4-yl)methanol 
• 217487-18-8 1-methanesulfonylpiperidine-4-carboxylic acid ethyl ester 
• 2033-24-1 cycl-isopropylidene malonate 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 216393-57-6 2-(3,5-difluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 937282-79-6 isopropyl 3-(1-methanesulfonylpiperidin-4-yl)propenoate 
• 124-63-0 methanesulfonyl chloride 
• 527693-82-9 3-[N-(benzyloxycarbonylpiperidin-4-yl)]propenoic acid 

Downstream Products

• 718610-74-3 (3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)piperidin-4-yl]propan-1-ol 
• 718610-25-4 (R) 3-(1-methanesulphonylpiperidin-4-yl)-3-[3,5-difluorophenyl]propionaldehyde 
• 835876-98-7 1-(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)piperidin-4-yl]propyl}piperidin-4-yl)methanamine 
• 835876-97-6 tert-butyl [(1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)-piperidin-4-yl]propyl}piperidin-4-yl)methyl]carbamate 
• 718610-24-3 (R) N-(3-[3,5-difluorophenyl]-3-[1-methanesulphonylpiperidin-4-yl]propyl)-4-[2-(4-methanesulphonylphenylsulphonyl)-ethyl]piperidine 

Relevant articles and documents

Development of an enantioselective, kilogram-scale, rhodium-catalysed 1,4-addition

A rhodium-catalysed 1,4-addition of an arylboron species to an α,β-unsaturated ester was the key chirality-inducing step in the synthesis of an API. We describe herein the development of this chemistry, including optimization of reagent charges, reaction

Chemical Compound

The present invention relates to 4-{(1R,3R)-1-(3,5-difluorophenyl)-3-[4-(3-ethyl-5-isopropyl-4H-1,2,4-triazol-4-yl)piperidin-1-yl]butyl}-1-(methylsulfonyl)piperidine (I): or a pharmaceutically acceptable salt thereof, as well as to processes for preparing

PIPERIDINE OR 8-AZA-BICYCLO[3.2.1]OCT-3-YL DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Compounds of formula (I): wherein R1, R2, R3, R4, A and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activit