719304-92-4

Basic information

• Product Name: 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline
• Synonyms: 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline
• CAS NO: 719304-92-4
• Molecular Weight: 510.977
• Mol File: 719304-92-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline(719304-92-4)
• EPA Substance Registry System: 4-(5-chloro-2-methoxypyridin-4-ylamino)-7-(2, 4-dimethoxybenzyloxy) - 5-isopropoxyquinazoline(719304-92-4)

Safety Data

• Hazardous Substances Data: 719304-92-4(Hazardous Substances Data)

Upstream product

• 7314-44-5 2,4-dimethoxylbenzyl alcohol 
• 13473-01-3 5-chloro-2-methoxypyridine 
• 557771-28-5 7-fluoro-5-isopropoxyquinazolin-4(3H)-one 
• 379228-58-7 5,7-difluoroquinazolin-4(3H)-one 
• 719305-31-4 5-chloro-2-methoxypyridine-1-oxide 
• 719305-30-3 5-chloro-2-methoxypyridin-4-amine 
• 692059-53-3 4-chloro-7-(2, 4-dimethoxybenzyloxy)-5 isopropoxyquinazoline 

Relevant articles and documents

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and physical properties suitable for oral dosing were achieved within this series: 23d and 42 were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.