71998-69-1Relevant articles and documents
A convenient synthesis of the enantiomerically pure (S)-2,4-dihydroxybutyl-4-hydroxybenzoate using hydrolytic kinetic resolution
More, Namita A.,Jadhao, Nitin L.,Garud, Dinesh R.,Gajbhiye, Jayant M.
supporting information, p. 2093 - 2098 (2018/07/15)
(S)-2,4-Dihydroxybutyl-4-hydroxybenzoate was prepared in an extremely simple and practical way with high enantiomeric excess (99% ee) using Jacobsen’s Hydrolytic Kinetic Resolution technique as a key step and source of chirality.
Intramolecular thermal stepwise [2 + 2] cycloadditions: Investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones
Throup, Adam,Patterson, Laurence H.,Sheldrake, Helen M.
supporting information, p. 9554 - 9559 (2016/10/22)
Fused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we investigated an intramolecular variant of the thermal enamine [2 + 2] cyclisation, developing a diastereoselective intramolecular enamine [2 + 2] cyclisation furnishing δ lactone and lactam fused cyclobutenes in good yield and excellent diastereoselectivity.
Synthesis of Novel C-Pivot Lariat 18-Crown-6 Ethers and Their Efficient Purification
Jana, Susovan,Suresh, Vallabh,Lepore, Salvatore D.
, p. 1977 - 1980 (2015/09/01)
The syntheses of various lariat ethers including several not previously reported and their efficient purification are presented. The synthesis route brings together reactions from a variety of previous works leading to a robust and generalized approach to these C-pivot lariats. The main steps are condensation of functionalized diols with pentaethylene glycol ditosylate in the presence of potassium as a templating cation. Purification of the final products was achieved without chromatography by extracting from an aqueous potassium hydroxide solution.
