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72136-99-3

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72136-99-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72136-99-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,1,3 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 72136-99:
(7*7)+(6*2)+(5*1)+(4*3)+(3*6)+(2*9)+(1*9)=123
123 % 10 = 3
So 72136-99-3 is a valid CAS Registry Number.

72136-99-3Upstream product

72136-99-3Relevant articles and documents

Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist

Jiang, Weiqin,Fiordeliso, James J.,Allan, George,Linton, Olivia,Tannenbaum, Pamela,Xu, Jun,Zhu, Peifang,Gunnet, Joseph,Demarest, Keith,Lundeen, Scott,Sui, Zhihua

, p. 1471 - 1474 (2007)

Mifepristone is a non-selective antagonist of 3-oxosteroid receptors with both abortifacient and anti-diabetic activities. For glucocorticoid receptor (GR) program, we sought an unexplored, synthetically accessible phosphorus-containing steroidal mimetic of mifepristone, suitable for parallel synthesis of analogues. One compound 4a, with high oral bioavailability (59%) in rat, exhibited functional antagonism of GR in oral glucose tolerance test (OGTT). Thus this series of compounds might be potentially useful for the treatment of type II diabetes.

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