72275-67-3

Basic information

• Product Name: ASTROMICINSULFATE
• Synonyms: L-Chiro-inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-o-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-o-methyl-, disulfate;L-Chiro-inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-o-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-o-methylsulfate (1:2) (salt);Unii-poy3S0T3bd;ASTROMICINSULFATE;2-amino-N-[(1R,2R,3R,4R,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-amin oethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acet amide: sulfuric acid;Abbott 44747;Fortimicin A disulfate;Fortimicin A sulfate
• CAS NO: 72275-67-3
• Molecular Formula: C₁₇H₃₅N₅O₆*H₂O₄S
• Molecular Weight: 601.73
• Mol File: 72275-67-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ASTROMICINSULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: ASTROMICINSULFATE(72275-67-3)
• EPA Substance Registry System: ASTROMICINSULFATE(72275-67-3)

Safety Data

• Hazardous Substances Data: 72275-67-3(Hazardous Substances Data)

Usage

Description

Astromicin sulfate is a pseudodisaccharide aminoglycoside antibiotic with a spectrum comparable to amikacin. It is active against many gentamicin and amikacin resistant bacteria expressing aminoglycoside-modifying enzymes, with the exception of aminoglycoside 3-acetyltransferase.

Brand name

FORTIMICIN

Therapeutic Function

Antibiotic

InChI:InChI=1/C17H35N5O6.2H2O4S/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18;2*1-5(2,3)4/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3;2*(H2,1,2,3,4)/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+;;/m0../s1

Upstream product

• 76801-55-3 1,2',6'-tri-N-acetyl-2-epi-fortimicin B 4,5-carbamate 
• 54783-95-8 2-epi-fortimicin B 
• 66962-56-9 1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A 
• 66962-55-8 1,2',6'-tri-N-benzyloxycarbonyl-2-epi-fortimicin B 
• 76801-51-9 1,2',6',2''-tetra-N-benzyloxycarbonyl-2-O-(N-benzyloxycarbonyl)glycyl-2-epi-fortimicin A 
• 76801-60-0 2-O-benzyl-1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A 
• 76801-59-7 2-O-benzyl-1,2',6'-tri-N-benzyloxycarbonyl-2-epi-fortimicin B 
• 76801-57-5 1,2',6'-tri-N-acetyl-2-O-benzyl-2-epi-fortimicin B 4,5-carbamate 
• 76801-58-6 2-O-benzyl-2-epi-fortimicin B 
• 67010-18-8 2-epi-fortimicin A tetrahydrochloride 
• 54783-95-8 6'-epi-fortimicin B 
• 66962-56-9 1,2',6',2-tetra-N-benzyloxycarbonyl-6'-epi-fortimicin B 
• 66962-55-8 1,2',6'-tri-N-benzyloxycarbonyl-6'-epi-fortimicin B 
• 78740-87-1 1,2-di-N-benzyloxycarbonyl-6'-epi-fortimicin B-4,5-carbamate 

Downstream Products

• 72351-18-9 1,4-bis-N-(benzyloxycarbonyl)fortamine B 
• 54783-95-8 fortimicin B 
• 71241-90-2 2'-N-glycylfortimicin B 

Relevant articles and documents

PREPARATIONS OF 2-epi-FORTIMICINS A FROM 2-epi-FORTIMICIN B BY INTRAMOLECULAR BASE-CATALYZED 2-O-ACYLATION OF 1,2',6'-TRI-N-BENZYLOXYCARBONYL-2-EPI-FORTIMICIN B

Preparation of 2-epi-fortimicin A (4) from 2-epi-fortimicin B (3) are described.In contrast to the previously reported, selective 4-N-acylation of 1,2',6'-tri-N-benzyloxycarbonylfortimicin B (8) with N-(N-benzyloxycarbonylglycyloxy)succinimide, 1,2',6'-tr

Fortimicin B derivatives and process for production thereof

The present invention relates to certain novel 4-N-substituted derivatives of the antibiotic Fortimicin B and processes for production thereof. Included in the process aspect of the invention, is a novel method for the semi-synthetic production of the antibiotic Fortimicin C.