- Fortimicin a
- Fortimicin a sulfate
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| Name |
Fortimicin a sulfate |
EINECS | N/A |
| CAS No. | 72275-67-3 | Density | 1.31 g/cm3 |
| PSA | 192.54000 | LogP | -0.78420 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C17H35N5O6•2H2O4S | Boiling Point | 621.1oC at760mmHg |
| Molecular Weight | 503.574 | Flash Point | 329.4oC |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of SOx and NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
ASTROMICINSULFATE;2-amino-N-[(1R,2R,3R,4R,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-amin oethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxy-cyclohexyl]-N-methyl-acet amide: sulfuric acid;Abbott 44747;Fortimicin A disulfate;Fortimicin A sulfate;L-chiro-Inositol, 4-amino-1-[(aminoacetyl)methylamino]-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-, sulfate (1:2) (salt) |
Article Data | 2 |
Fortimicin a sulfate Chemical Properties
IUPAC Name: 2-Amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide; sulfuric acid
Synonyms of Fortimicin a sulfate (CAS NO.72275-67-3) : 4-Amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol sulfate (1:2) (salt) Astromicin sulfate ; Fortimicin A sulfate ; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-, disulfate ; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methylsulfate (1:2) (salt)
CAS NO:72275-67-3
Molecular Formula:C17H39N5O14S2
Molecular Weight :601.6467
Molecular Structure :.png)
Fortimicin a sulfate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intramuscular | 750mg/kg (750mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Chemotherapy Vol. 29(Suppl, |
| dog | LD50 | intravenous | 214mg/kg (214mg/kg) | Chemotherapy Vol. 29(Suppl, | |
| guinea pig | LD50 | intramuscular | 611mg/kg (611mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980. |
| mouse | LD50 | intramuscular | 427mg/kg (427mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Chemotherapy Vol. 29(Suppl, |
| mouse | LD50 | intraperitoneal | 533mg/kg (533mg/kg) | Chemotherapy Vol. 29(Suppl, | |
| mouse | LD50 | intravenous | 94mg/kg (94mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980. |
| mouse | LD50 | oral | 13600mg/kg (13600mg/kg) | Chemotherapy Vol. 29(Suppl, | |
| mouse | LD50 | subcutaneous | 546mg/kg (546mg/kg) | Yakkyoku. Pharmacy. Vol. 36, Pg. 967, 1985. | |
| rabbit | LD50 | intravenous | 654mg/kg (654mg/kg) | Drugs in Japan Vol. -, Pg. 19, 1995. | |
| rat | LD50 | intramuscular | 1009mg/kg (1009mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980. |
| rat | LD50 | intraperitoneal | 913mg/kg (913mg/kg) | Chemotherapy Vol. 29(Suppl, | |
| rat | LD50 | intravenous | 86mg/kg (86mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toxicology and Applied Pharmacology. Vol. 53, Pg. 399, 1980. |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Chemotherapy Vol. 29(Suppl, | |
| rat | LD50 | subcutaneous | 1364mg/kg (1364mg/kg) | Chemotherapy Vol. 29(Suppl, |
Fortimicin a sulfate Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. An experimental teratogen. When Fortimicin a sulfate (CAS NO.72275-67-3) is heated to decomposition ,it emits very toxic fumes of SOx and NOx.
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